Recombinant Human Fas apoptotic inhibitory molecule 3 (FAIM3), partial

Code CSB-YP007972HU1
MSDS
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Source Yeast
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Code CSB-EP007972HU1
MSDS
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Source E.coli
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Code CSB-EP007972HU1-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP007972HU1
MSDS
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Source Baculovirus
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Code CSB-MP007972HU1
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
FCMR
Uniprot No.
Alternative Names
FCMR; FAIM3; TOSO; Fas apoptotic inhibitory molecule 3; IgM Fc fragment receptor; Regulator of Fas-induced apoptosis Toso
Species
Homo sapiens (Human)
Protein Length
Partial
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation.
Gene References into Functions
  1. Overexpression of TOSO gene is associated with chronic lymphocytic leukemia. PMID: 21264533
  2. Toso/FcmuR is an IgM receptor capable of activating signaling molecules and whose expression alone is not inherently antiapoptotic. PMID: 22675200
  3. Overexpression of TOSO in chronic lymphocytic leukemia is associated with disease progression. PMID: 21756805
  4. Enhanced levels of both membrane-bound and soluble forms of FcmuR in CLL patients. PMID: 21908424
  5. TOSO/FAIM3 may play a role in immune surveillance and contribute to B cell activation PMID: 21908732
  6. TOSO is overexpressed and correlated with disease progression in chronic lymphocytic leukemia. PMID: 21133733
  7. This review focuses on possible functional consequences of Plasmodium falciparum EMP1 protein interaction with the IgM receptor, including interference with immunologic signaling and clearance mechanisms and blocking of specific antibody binding. PMID: 20410497
  8. These results identify TOSO/FAIM3 as a receptor for IgM PMID: 20042454
  9. enzymatically modified-LDL-generated foam cells are protected from cell death most likely through the expression of TOSO by a FLIP(L) independent mechanism PMID: 17553462
  10. demonstrated a 5.6-fold increase of TOSO protein in circulating CLL cells and lymph nodes PMID: 18434611
  11. association with unmutated IgV(H) and the specific induction of TOSO via the BCR suggest autoreactive BCR signaling as a key mediator of apoptosis resistance in CLL. PMID: 18708628
  12. TOSO as a mediator of resistance to apoptosis in chronic lymphocytic leukemia [review] PMID: 19347734
  13. Although this receptor was initially designated as Fas apoptotic inhibitory molecule 3, or TOSO, our results indicate that FcmuR per se has no inhibitory activity in Fas-mediated apoptosis PMID: 19858324

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Subcellular Location
[Isoform 1]: Membrane; Single-pass membrane protein.; [Isoform 3]: Secreted.
Tissue Specificity
Expressed in lymph nodes, peripheral blood leukocytes, lung, thymus and kidneys. Very weak expression detected in spleen, liver, heart, and salivary gland. Expressed in lymphoid cell lines such as Jurkat, CEM-T4, MOLT-4, HB11;19 and Reh. No expression det
Database Links

HGNC: 14315

OMIM: 606015

KEGG: hsa:9214

STRING: 9606.ENSP00000356058

UniGene: Hs.58831

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