FBXL2 Antibody, HRP conjugated

Datasheet

Code	CSB-PA892134LB01HU
Size	US$166
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) FBXL2 Polyclonal antibody

Uniprot No.

Q9UKC9

Target Names

FBXL2

Alternative Names

DKFZP564P0622 antibody; F box and leucine rich repeat protein 2 antibody; F box protein containing leucine rich repeats antibody; F box protein FBL2/FBL3 antibody; F box/LRR repeat protein 2 antibody; F-box and leucine-rich repeat protein 2 antibody; F-box protein FBL2/FBL3 antibody; F-box/LRR-repeat protein 2 antibody; FBL 2 antibody; FBL 3 antibody; FBL2 antibody; FBL3 antibody; FBXL 2 antibody; FBXL2 antibody; FBXL2_HUMAN antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human F-box/LRR-repeat protein 2 protein (1-423AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

HRP

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Calcium-activated substrate recognition component of the SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex, SCF(FBXL2), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin-binding motifs and is thereby antagonized by calmodulin. This is the case for the cyclins CCND2 and CCND3 which polyubiquitination and subsequent degradation are inhibited by calmodulin. Through CCND2 and CCND3 degradation induces cell-cycle arrest in G(0). SCF(FBXL2) also mediates PIK3R2 ubiquitination and proteasomal degradation thereby regulating phosphatidylinositol 3-kinase signaling and autophagy. PCYT1A monoubiquitination by SCF(FBXL2) and subsequent degradation regulates synthesis of phosphatidylcholine, which is utilized for formation of membranes and of pulmonary surfactant.

Gene References into Functions

PTEN counteracts FBXL2 to promote IP3R3- and Ca(2+)-mediated apoptosis limiting tumour growth PMID: 28614300
these results uncover a previous unknown network involving FBXL2 and FoxM1 in the regulation of gastric cancer growth. PMID: 26790640
FBXL2 recognizes Trp-73 within NALP3 for interaction and targets Lys-689 within NALP3 for ubiquitin ligation and degradation. PMID: 26037928
FBXL2 mediates the ubiquitylation and degradation of p85beta on cell membranes. PMID: 23604317
These results suggested that the involvement of the reduction of FBL2 level is related to AD progression. PMID: 22455980
FBXL2 is indispensible regulator of mitosis that serves as a tumor suppressor PMID: 22020328
FBXL2 targets cyclin D2 for ubiquitination and degradation to inhibit leukemic cell proliferation. PMID: 22323446
FBL2 is a novel and dual regulator of amyloid precursor protein (APP) metabolism through FBL2-dependent ubiquitination of APP. PMID: 22399757

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Subcellular Location

Membrane; Lipid-anchor.

Tissue Specificity

Expressed in brain, heart, kidney, liver, lung, pancreas and placenta.

Database Links

HGNC: 13598

OMIM: 605652

KEGG: hsa:25827

STRING: 9606.ENSP00000417601

UniGene: Hs.475872

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Phage Display Service

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Protein Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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