Name: FBXO3 Antibody, Biotin conjugated
Brand: CUSABIO
SKU: CSB-PA892132LD01HU

Product Details

Full Product Name	Rabbit anti-Homo sapiens (Human) FBXO3 Polyclonal antibody
Uniprot No.	Q9UK99
Target Names	FBXO3
Alternative Names	F Box G - Domain 3 antibody; F box only protein 3 antibody; F box protein 3 antibody; F box protein FBX3 antibody; F-box only protein 3 antibody; FBA antibody; FBX3 antibody; FBX3_HUMAN antibody; FBXO3 antibody
Raised in	Rabbit
Species Reactivity	Human
Immunogen	Recombinant Human F-box only protein 3 protein (276-376AA)
Immunogen Species	Homo sapiens (Human)
Conjugate	Biotin
Clonality	Polyclonal
Isotype	IgG
Purification Method	>95%, Protein G purified
Concentration	It differs from different batches. Please contact us to confirm it.
Buffer	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form	Liquid
Tested Applications	ELISA
Protocols	ELISA Protocol
Troubleshooting and FAQs	Antibody FAQs
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time	Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function	Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation.
Gene References into Functions	we report the X-ray structure of the human FBxo3 ApaG domain, residues 278-407, at 2.0 A resolution PMID: 27010866 AIRE, which is phosphorylated on two specific residues near its N terminus, then binds to the F-box protein 3 (FBXO3) E3 ubiquitin ligase. In turn, this SCF(FBXO3) (SKP1-CUL1-F box) complex ubiquitylates AIRE, increases its binding to the positive transcription elongation factor b (P-TEFb), and potentiates its transcriptional activity. PMID: 27365398 Fbxo3 promotes the proteasomal degradation of Smurf1. Fbxo3 promotes the poly-ubiquitination of Smurf1. PMID: 25721664 Virulence factor NSs of rift valley fever virus recruits the FBXO3 to degrade subunit p62 of general transcription factor TFIIH. PMID: 24403578 controls TRAF adaptor stability to regulate inflammation PMID: 23542741 Fbx3 formed SCF(Fbx3) ubiquitin ligase and promoted the degradation of HIPK2 and p300 by the ubiquitin-proteasome pathway PMID: 18809579 Show More Hide All
Subcellular Location	Nucleus. Note=Colocalizes with PML at the peripheries of nuclear bodies.
Database Links	HGNC: 13582 OMIM: 609089 KEGG: hsa:26273 STRING: 9606.ENSP00000265651 UniGene: Hs.406787

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Code	CSB-PA892132LD01HU
Size	US$299
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FBXO3 Antibody, Biotin conjugated

Product Details

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Target Background

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