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| Code | CSB-PA008495GA01HU |
| Size | $600 |
| Have Questions? | Leave a Message or Start an on-line Chat |
| Uniprot No. | Q9UK99 |
| Target Names | FBXO3 |
| Alternative Names |
F Box G - Domain 3 antibody; F box only protein 3 antibody; F box protein 3 antibody; F box protein FBX3 antibody; F-box only protein 3 antibody; FBA antibody; FBX3 antibody; FBX3_HUMAN antibody; FBXO3 antibody
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| Raised in | Rabbit |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Human FBXO3 |
| Immunogen Species | Homo sapiens (Human) |
| Isotype | IgG |
| Purification Method | Antigen Affinity purified |
| Concentration | It differs from different batches. Please contact us to confirm it. |
| Buffer | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| Tested Applications | ELISA,WB |
| Protocols | ELISA Protocol Western Blotting(WB) Protocol |
| Troubleshooting and FAQs | Antibody FAQs |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Lead Time | Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time. |
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| Function |
Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation.
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| Gene References into Functions |
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| Subcellular Location | Nucleus. Note=Colocalizes with PML at the peripheries of nuclear bodies. |
| Database Links |
HGNC: 13582 OMIM: 609089 KEGG: hsa:26273 STRING: 9606.ENSP00000265651 UniGene: Hs.406787 |
