FBXW2 Antibody

Code CSB-PA008524GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
FBXW2
Alternative Names
F box and WD 40 domain containing protein 2 antibody; F box and WD repeat domain containing 2 antibody; F box and WD40 domain protein 2 antibody; F box/WD repeat containing protein 2 antibody; F-box and WD-40 domain-containing protein 2 antibody; F-box/WD repeat-containing protein 2 antibody; FBW 2 antibody; FBW2 antibody; FBXW 2 antibody; Fbxw2 antibody; FBXW2_HUMAN antibody; Fwd2 antibody; Md6 antibody; Protein MD6 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human FBXW2
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IHC
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
Gene References into Functions
  1. BTrCP-FBXW2-SKP2 axis forms an oncogene-tumour suppressor-oncogene cascade to control cancer cell growth with FBXW2 acting as a tumour suppressor by promoting SKP2 degradation. PMID: 28090088
  2. RACK1 competes with GCM1 for FBW2 and thereby prevents GCM1 ubiquitination, which is also supported by the observation that GCM1 is destabilized in RACK1-knockdown BeWo placental cells PMID: 23651062
  3. the SCF(hFBW2) E3 complex has a key role in targeting hGCMa to the ubiquitin-proteasome degradation system PMID: 15640526
  4. UBE2D2 is required for GCMa ubiquitination and for association with the SCF(FBXW2) complex. PMID: 18703417
Database Links

HGNC: 13608

OMIM: 609071

KEGG: hsa:26190

STRING: 9606.ENSP00000363036

UniGene: Hs.494985

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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