FBXW2 Antibody, FITC conjugated

Code CSB-PA891730LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) FBXW2 Polyclonal antibody
Uniprot No.
Target Names
FBXW2
Alternative Names
F box and WD 40 domain containing protein 2 antibody; F box and WD repeat domain containing 2 antibody; F box and WD40 domain protein 2 antibody; F box/WD repeat containing protein 2 antibody; F-box and WD-40 domain-containing protein 2 antibody; F-box/WD repeat-containing protein 2 antibody; FBW 2 antibody; FBW2 antibody; FBXW 2 antibody; Fbxw2 antibody; FBXW2_HUMAN antibody; Fwd2 antibody; Md6 antibody; Protein MD6 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human F-box/WD repeat-containing protein 2 protein (72-340AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
Gene References into Functions
  1. BTrCP-FBXW2-SKP2 axis forms an oncogene-tumour suppressor-oncogene cascade to control cancer cell growth with FBXW2 acting as a tumour suppressor by promoting SKP2 degradation. PMID: 28090088
  2. RACK1 competes with GCM1 for FBW2 and thereby prevents GCM1 ubiquitination, which is also supported by the observation that GCM1 is destabilized in RACK1-knockdown BeWo placental cells PMID: 23651062
  3. the SCF(hFBW2) E3 complex has a key role in targeting hGCMa to the ubiquitin-proteasome degradation system PMID: 15640526
  4. UBE2D2 is required for GCMa ubiquitination and for association with the SCF(FBXW2) complex. PMID: 18703417
Database Links

HGNC: 13608

OMIM: 609071

KEGG: hsa:26190

STRING: 9606.ENSP00000363036

UniGene: Hs.494985

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