FEZF1 Antibody, Biotin conjugated

Code CSB-PA008602LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) FEZF1 Polyclonal antibody
Uniprot No.
Target Names
FEZF1
Alternative Names
FEZ antibody; FEZ family zinc finger 1 antibody; Fez family zinc finger protein 1 antibody; fez like antibody; fezf1 antibody; FEZF1_HUMAN antibody; Zinc finger protein 312 like antibody; Zinc finger protein 312B antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Fez family zinc finger protein 1 protein (1-115AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Transcription repressor. Involved in the axonal projection and proper termination of olfactory sensory neurons (OSN). Plays a role in rostro-caudal patterning of the diencephalon and in prethalamic formation. Expression is required in OSN to cell-autonomously regulate OSN axon projections. Regulates non-cell-autonomously the layer formation of the olfactory bulb development and the interneurons. May be required for correct rostral migration of the interneuron progenitors.
Gene References into Functions
  1. FEZF1 was significantly increased in glioma tissues. Over-expressed FIZF1 was associated with reduced survival. PMID: 30030762
  2. loss of FEZF1 impairs the pluripotency exit of hESCs during neural specification, which partially explains the neural induction defect caused by FEZF1 deletion. PMID: 29318501
  3. FEZF1plays a novel role in regulating the malignant behavior of glioma stem cells as a part of Linc00152/miR-103a-3p/FEZF1/CDC25A axis.FEZF1 up-regulated the promoter activities and bound to the promoters of CDC25A in glioma stem cells. PMID: 28651608
  4. High expression of long noncoding RNA FEZF1 was significantly associated with later stage and higher grade of gastric cancer. PMID: 29239821
  5. SEZ6L, HISPPD1, FEZF1, SAMD11 gene variants may be associated with autism spectrum disorder. PMID: 26204995
  6. Fezf1 and Fezf2 accomplish both independent and redundant functions across diverse tissue and cell types. [Review] PMID: 24913420
  7. Mutations in FEZF1 cause Kallmann syndrome. PMID: 25192046
  8. the aberrant expression of ZNF312b promotes gastric tumorigenesis through epigenetic modification of its promoter region and provides a molecular mechanism for ZNF312b expression to contribute to the progression of gastric cancer. PMID: 21170990
  9. Study is the first to report that ZNF312b, a novel transcription factor, was associated with tumorigenicity of gastric cancer. PMID: 19318583
  10. Observational study of gene-disease association. (HuGE Navigator) PMID: 19401682

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Involvement in disease
Hypogonadotropic hypogonadism 22 with or without anosmia (HH22)
Subcellular Location
Nucleus.
Protein Families
Krueppel C2H2-type zinc-finger protein family
Tissue Specificity
Expressed in brain. Little or no expression in other tissues. Overexpressed specifically in gastric cancers. A 2- to 20-fold increase is found in over 50% of gastric cancer tissues.
Database Links

HGNC: 22788

OMIM: 613301

KEGG: hsa:389549

STRING: 9606.ENSP00000411145

UniGene: Hs.553970

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