FEZF1 Antibody

Datasheet
Code CSB-PA008602LA01HU
See More Details Free Antibody trial simple
Size US$299
Uniprot No. A0PJY2
Image
  • Western Blot
    Positive WB detected in: U251 whole cell lysate
    All lanes: FEZF1 antibody at 6µg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 53, 47, 52 kDa
    Observed band size: 53 kDa

  • IHC image of CSB-PA008602LA01HU diluted at 1:400 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunogen Recombinant Human Fez family zinc finger protein 1 protein (1-115AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA, WB, IHC; Recommended dilution: WB:1:500-1:5000, IHC:1:200-1:500
Relevance Transcription repressor. Involved in the axonal projection and proper termination of olfactory sensory neurons (OSN). Plays a role in rostro-caudal patterning of the diencephalon and in prethalamic formation. Expression is required in OSN to cell-autonomously regulate OSN axon projections. Regulates non-cell-autonomously the layer formation of the olfactory bulb development and the interneurons. May be required for correct rostral migration of the interneuron progenitors (By similarity).
Form Liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Fez family zinc finger protein 1 (Zinc finger protein 312B), FEZF1, FEZ ZNF312B
Immunogen Species Human
Research Area Neuroscience
Target Names FEZF1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Transcription repressor. Involved in the axonal projection and proper termination of olfactory sensory neurons (OSN). Plays a role in rostro-caudal patterning of the diencephalon and in prethalamic formation. Expression is required in OSN to cell-autonomously regulate OSN axon projections. Regulates non-cell-autonomously the layer formation of the olfactory bulb development and the interneurons. May be required for correct rostral migration of the interneuron progenitors (By similarity).
Involvement in disease Hypogonadotropic hypogonadism 22 with or without anosmia (HH22)
Subcellular Location Nucleus
Protein Families Krueppel C2H2-type zinc-finger protein family
Tissue Specificity Expressed in brain. Little or no expression in other tissues. Overexpressed specifically in gastric cancers. A 2-to 20-fold increase is found in over 50% of gastric cancer tissues.
Database Links

HGNC: 22788

OMIM: 613301

KEGG: hsa:389549

STRING: 9606.ENSP00000411145

UniGene: Hs.553970

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