FGF16 Antibody, FITC conjugated

Code CSB-PA008621LC01HU
Size US$299
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) FGF16 Polyclonal antibody
Uniprot No. O43320
Target Names FGF16
Alternative Names FGF 16 antibody; FGF-16 antibody; Fgf16 antibody; FGF16_HUMAN antibody; Fibroblast growth factor 16 antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Fibroblast growth factor 16 protein (1-207AA)
Immunogen Species Homo sapiens (Human)
Conjugate FITC
Clonality Polyclonal
Isotype IgG
Purification Method Antigen Affinity Purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
(From Uniprot)
Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation, and is required for normal cardiomyocyte proliferation and heart development.
Gene References into Functions
  1. Experiments demonstrated FGF16 could promote proliferation of NCL-H460 cells by activating Akt, Erk1/2, and p38 MAPK signaling, whereas JNK had no significant effect. PMID: 28409700
  2. Identification of an FGF16 mutation in metacarpal 4-5 fusion. PMID: 24878828
  3. impaired FGF16 function may also be responsible for connective tissue symptoms in MF4 patients. PMID: 24706454
  4. Fgf-16 gene is a target for NF-kappaB activation in the postnatal heart. PMID: 20097674
  5. HUVEC clearly demonstrated chemotaxis towards FGF16. FGF16 enhanced cell migration in response to mechanical damage & failed to induce endothelial cell proliferation or sprouting in a three-dimensional in vitro angiogenesis assay. PMID: 16756958

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Involvement in disease Metacarpal 4-5 fusion (MF4)
Subcellular Location Secreted.
Protein Families Heparin-binding growth factors family
Database Links

HGNC: 3672

OMIM: 300827

KEGG: hsa:8823

STRING: 9606.ENSP00000399324

UniGene: Hs.666364

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