FIGNL1 Antibody

Code CSB-PA008677GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
FIGNL1
Alternative Names
FIGNL1Fidgetin-like protein 1 antibody; EC 3.6.4.- antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human FIGNL1
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Involved in DNA double-strand break (DBS) repair via homologous recombination (HR). Recruited at DSB sites independently of BRCA2, RAD51 and RAD51 paralogs in a H2AX-dependent manner. May regulate osteoblast proliferation and differentiation. May play a role in the control of male meiosis dynamic.
Gene References into Functions
  1. FIGL-1 is a new centrosomal protein and inhibits ciliogenesis. PMID: 27384458
  2. Further research assessing the functions and mechanisms of FIGNL1, and other homologous recombination pathway genes may disclose unique pathological characteristics of SCLC, and help identify potential therapeutic targets and biomarkers PMID: 28260065
  3. RAD51-binding protein fidgetin-like 1 (FIGNL1) is identified; FIGNL1 specifically interacts with RAD51 through its conserved RAD51 binding domain. Cells depleted of FIGNL1 show defective homologous recombination repair. PMID: 23754376
Subcellular Location
Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Note=Together with RAD51 and a subset of H2A histone proteins, redistributed in discrete nuclear DNA damage-induced foci after ionizing radiation (IR) treatment (PubMed:23754376).
Protein Families
AAA ATPase family
Database Links

HGNC: 13286

OMIM: 615383

KEGG: hsa:63979

STRING: 9606.ENSP00000349356

UniGene: Hs.137516

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