FOLR2 Antibody, FITC conjugated

Code CSB-PA008786LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) FOLR2 Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
beta hFR antibody; FBP antibody; FBP/PL 1 antibody; FBP2 antibody; fetal/placental antibody; folate receptor 2 (fetal) antibody; Folate receptor 2 antibody; Folate receptor antibody; Folate receptor beta antibody; Folate receptor; fetal/placental antibody; Folbp 2 antibody; Folbp2 antibody; Folr2 antibody; FOLR2_HUMAN antibody; FR beta antibody; FR P3 antibody; FR-beta antibody; Placental folate binding protein antibody; Placental folate-binding protein antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Folate receptor beta protein (35-167AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function
Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release.
Gene References into Functions
  1. Folate receptor beta as a novel CD11b/CD18 regulator for trafficking and homing of a subset of macrophages on collagen. PMID: 27534550
  2. FR-beta expression was low or absent in the majority of ovarian, breast and colorectal tumor samples. PMID: 26248049
  3. FR-beta is uniquely expressed on this proinflammatory subpopulation offers a new strategy to suppress migration of inflammatory monocytes into sites of inflammation. PMID: 25015955
  4. High FOLR2 mRNA expression is associated with uraemic patients on hemodialysis. PMID: 23439585
  5. severe pre-eclampsia is associated with decreased placental expression of FR-beta and a reduction in the number of fetal macrophages (Hofbauer cells) PMID: 23480364
  6. Expression of folate receptor-beta on activated macrophages holds a promising potential for early diagnosis of atherosclerosis. (Review) PMID: 22094710
  7. High Folate Receptor beta expressing tumor-associated macrophages are associated with pancreatic cancer. PMID: 22350599
  8. Functional FR-beta present on osteoarthritis synovial macrophages provides a potential tool for the diagnosis and treatment of this disease. PMID: 22211358
  9. study describes that functional FRbeta is specifically expressed by M-CSF-polarized (M2) macrophages as well as by ex vivo isolated tumor-associated macrophages, and that tumors induce its expression in an M-CSF-dependent manner PMID: 19951991
  10. FR-beta gene is a target for multiple coordinate actions of nuclear receptors for ATRA directly and indirectly acting on a transcriptional complex containing activating Sp1/ets and inhibitory AP-1 proteins. PMID: 12543860

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Subcellular Location
Cell membrane; Lipid-anchor, GPI-anchor. Secreted.
Protein Families
Folate receptor family
Tissue Specificity
Expressed in placenta and hematopoietic cells. Expression is increased in malignant tissues.
Database Links

HGNC: 3793

OMIM: 136425

KEGG: hsa:2350

STRING: 9606.ENSP00000298223

UniGene: Hs.433159

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