FOSB Antibody

Code CSB-PA002563
Size US$100
Order now
Image
  • Western Blot analysis of 293 cells using Fos B Polyclonal Antibody
Have Questions? Leave a Message or Start an on-line Chat

Product Details

Uniprot No.
Target Names
FOSB
Alternative Names
Activator protein 1 antibody; AP 1 antibody; DKFZp686C0818 antibody; FBJ murine osteosarcoma viral oncogene homolog B antibody; fosB antibody; FOSB_HUMAN antibody; G0/G1 switch regulatory protein 3 antibody; G0S3 antibody; GOS 3 antibody; GOS B antibody; GOS3 antibody; GOSB antibody; MGC42291 antibody; Oncogene FOS B antibody; Oncogene FOSB antibody; Protein fos B antibody; Protein fosB antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Monkey
Immunogen
Synthesized peptide derived from Human Fos B around the non-phosphorylation site of S27.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, IHC, IF, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:20000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

 Customer Reviews
Average Rating:
5.0 - 1 reviews

Submit a Review here

Applications : Western Blot Analysis

Sample dilution: 1:500

Review: Western blotting analysis of c-fos and fosB expression in the prefrontal cortex from the model group and control group. The expression of fosB protein in the prefrontal cortex of the model group was also significantly increased compared with the control group.

By Anonymous

Target Background

Function
FosB interacts with Jun proteins enhancing their DNA binding activity.
Gene References into Functions
  1. miR-144-3p plays an important role in pancreatic cancer cell proliferation, migration, and invasion by targeting FOSB PMID: 28653602
  2. FOSB immunohistochemistry is sensitive in the diagnosis of angiolymphoid hyperplasia with eosinophilia, and allows differentiation from its histological mimics PMID: 29527734
  3. FOSB overexpression results in TNBC cell death, whereas inhibition of calcium signaling eliminates FOSB induction and blocks TP4-induced TNBC cell death PMID: 27248170
  4. results shows the involvement of Spry2 in regulation of FosB and Runx2 genes, MAPK signaling and proliferation of mesenchymal stem cells. PMID: 28387432
  5. the mechanism underlying redox-regulation of AP-1 Fos/Jun transcription factors and provide structural insight for therapeutic interventions targeting AP-1 proteins. PMID: 28981703
  6. The NFATc3 first induced the expression of its interaction partner FosB before forming the heterodimeric NFATc3-FosB transcription factor complex, which bound the proximal AP-1 site in the TF gene promoter and activated TF expression. PMID: 28724635
  7. FosB expression in the prefrontal cortex and hippocampus of the cocaine addicted and depression patients PMID: 27494187
  8. FOSB is a highly sensitive and diagnostically useful marker for pseudomyogenic hemangioendothelioma. PMID: 28009608
  9. our findings show that DeltaFosB increases the expression of MMP-9 and exhibits a significantly high survival and proliferation in MCF-7 cells. PMID: 26608367
  10. Diffuse and strong FOSB expression was specific for pseudomyogenic hemangioendothelioma in the current series and FOSB immunohistochemistry is an effective tool for differentiating between PHE and its histological mimics. PMID: 27515856
  11. Our results using a number of approaches, such as promoter reporter assay, FosB knock down and Chip assay, suggest that the expression of miR-22 is regulated transcriptionally by FosB. PMID: 27889568
  12. These results suggest that SETDB1- mediated FosB expression is a common molecular phenomenon, and might be a novel pathway responsible for the increase in cell proliferation that frequently occurs during anticancer drug therapy. PMID: 26949019
  13. studies of FosB are providing new insight into the molecular basis of depression and antidepressant action. PMID: 25446562
  14. The abnormalities were screened by FISH in 44 epithelioid hemangioma (EH) from different locations with seven additional EH revealing FOSB gene rearrangements, all except one being fused to ZFP36. PMID: 25043949
  15. This study describing the expres-sion pattern of FosB/ FosB immunoreactivity inpost mortem basal ganglia sections from Parkinson disease patients. PMID: 23933656
  16. Pseudomyogenic haemangioendothelioma consistently displays a SERPINE1-FOSB fusion gene, resulting from a translocation between chromosomes 7 and 19. PMID: 24374978
  17. Data indicate a significant correlation in miR-181b, FOS and miR-21 expression glioma tissues. PMID: 23810250
  18. Report Fos-B expression in skin keratinocytes/fibroblasts and keloid fibroblasts exposed to genistein. PMID: 23614275
  19. AP-1 protein induction during monopoiesis favors C/EBP: AP-1 heterodimers over C/EBP homodimerization and stimulates FosB transcription. PMID: 21543584
  20. Induction of a DeltaFOSB mediated transcriptional pattern in the prefrontal cortex is opposite to the down-regulation observed in the nucleus accumbens in patients with major depressive disorder PMID: 21616539
  21. Findings indicate that neurobehavioral stress leads to FosB-driven increases in IL8, which is associated with increased tumor growth and metastases. PMID: 20826776
  22. transcription factor FosB/activating protein-1 (AP-1) activation is a prominent downstream signal of the extracellular nucleotide receptor P2RX7 in monocytic and osteoblastic cells PMID: 20813842
  23. RGS16 and FosB are underexpressed in pancreatic cancer with lymph node metastasis and associated with reduced survival PMID: 20571966
  24. demonstrated that a functional AP-1 site mediates MMP-2 transcription in cardiac cells through the binding of distinctive Fra1-JunB and FosB-JunB heterodimers. The synthesis of MMP-2 is considered to be independent of the AP-1 transcriptional complex PMID: 12371906
  25. AP-1 (c-Jun & FosB) binds to a site in the 5' untranslated region of the CD95L gene. Transdominant negative Jun mutants reduce CD95L promoter activity. FosB dimerized with c-Jun has an important role in TCR/CD3-mediated activation-induced cell death. PMID: 12618758
  26. In hepatoma-associated anorexia-cachexia FpsB was induced in several brain areas of thes forebrain. PMID: 15926923
  27. activation of protein kinase A elicits an immediate response through induction of genes such as ID2 and FosB, followed by sustained secretion of bone-related cytokines such as BMP-2, IGF-1, and IL-11 PMID: 18490653
  28. DeltaFosB was able to trigger partial Pref-1-mediated de-differentiation of adipocytes, which also retained their adipocytic cell phenotype. PMID: 18491952
  29. An IFN-gamma-mediated homeostatic loop limits the potential for tissue damage associated with inflammation and identifies transcriptional factor AP-1 that regulates matrix metalloproteinase expression in myeloid cells in inflammatory settings. PMID: 18802113
  30. MicroRNA-101, which is aberrantly expressed in hepatocellular carcinoma, could repress the expression of the FOS oncogene. PMID: 19133651
  31. FosB is induced in PMA treated K562 cells in a sustained manner and forms an active AP-1 protein-DNA complex. Down-regulation of FosB with specific shRNAs inhibited the induction of CD41, a specific cell surface marker of megakaryocytes. PMID: 19381435
  32. Results suggest that in addition to clinically prognostic factors, FOS-B expression has a debatable impact on patient survival. PMID: 19795327

Show More

Hide All

Subcellular Location
Nucleus.
Protein Families
BZIP family, Fos subfamily
Database Links

HGNC: 3797

OMIM: 164772

KEGG: hsa:2354

STRING: 9606.ENSP00000245919

UniGene: Hs.590958

icon of phone
Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
icon of address
Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
icon of social media
Join us with

Subscribe newsletter

Leave a message

* To protect against spam, please pass the CAPTCHA test below.
CAPTCHA verification
© 2007-2024 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1
webinars: DT3C facilitates antibody internalization X
Place an order now

I. Product details

*
*
*
*

II. Contact details

*
*

III. Ship To

*
*
*
*
*
*
*

IV. Bill To

*
*
*
*
*
*
*
*