GABRB1 (Ab-434) Antibody

1. No allelic association was detected in this study between tested SNPs and risk for developing alcohol dependence in a British and Irish population; however, modest genotypic associations were found with several intronic GABRbeta1 SNPs that may directly influence alcohol dependence risk or may be in linkage disequilibrium with causal risk variants in nearby genes, including other GABA receptor subunits PMID: 28346242
2. Results from genome-wide DNA methylation, functional network analysis and pyrosequencing, show selective CpG sites (NOS1AP, BID, and GABRB1) differentially methylated in smokers and chronic obstructive pulmonary disease patients compared to nonsmokers. PMID: 28416970
3. PCDHB14- and GABRB1-like nervous system developmental genes are altered during early neuronal differentiation of NCCIT cells treated with ethanol PMID: 25566775
4. This study showed that in male group the expression of GABRB1 was generally lower in schizophrenia cases compared to the control, but was higher in female group. PMID: 25660468
5. Both mRNA and protein of GABAB receptor subunits, GABAB1 and GABAB2, were co-expressed in cultured human RPE cells; GABAB receptors regulate the [Ca2+]i via a pertussis toxin-sensitive Gi/o-protein pathway and a phospholipase C pathway PMID: 25241062
6. study provides the first evidence for the involvement of the GABRB1 gene in the thalamus structure and their interactive effects on intelligence PMID: 25192656
7. This study demonstrates altered patterns of N-glycosylation of GABRB1 in the temporal lobe in schizophrenia. PMID: 23917429
8. GABRB1 protein levels were significantly decreased in schizophrenia, major depressive disorder, and bipolar disorder patients' lateral cerebellum compared to controls. PMID: 24022508
9. These results suggest that epigenetic control of gene expression may affect the expression of GABRB1 and disrupt inhibitory synaptic transmission during embryonic development. PMID: 23392927
10. Gaba-A receptor subunit beta1 is not involved in amygdala hyperexcitability of patients with temporal lobe epilepsy. PMID: 20848605
11. Gaba (A) beta1 and beta3 subunit mRNA levels in the dorsolateral prefrontal cortex are not altered in schizophrenia. PMID: 20843900
12. linkage disequilibrium between beta frequency of EEG and a set of GABA(A) receptor genes PMID: 11891318
13. A signal for GABA A beta 1 isoform mRNA transcript could not be detected in the competitive RT-PCR assay. PMID: 15337300
14. histamine modulates heteromultimeric GABA(A) receptors and may thus represent an endogenous ligand for an allosteric site PMID: 18281286
15. three distinct sets of amino acid residues in the N-terminal extracellular domain of the hbeta1 subunit, which when mutated to the homologous residue in hbeta3 allow expression as a functional homomeric receptor PMID: 18650446

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HGNC: 4081

OMIM: 137190

KEGG: hsa:2560

STRING: 9606.ENSP00000295454

UniGene: Hs.254117