Product Details

Uniprot No.

Target Names

GABRB1

Alternative Names

AW061132 antibody; B230208N19Rik antibody; GABA(A) receptor beta 1 antibody; GABA(A) receptor subunit beta-1 antibody; GABA-A receptor; beta-1 polypeptide antibody; Gabrb-1 antibody; GABRB1 antibody; Gamma aminobutyric acid (GABA) A receptor beta 1 antibody; Gamma Aminobutyric Acid A Receptor Beta 1 antibody; Gamma Aminobutyric Acid Receptor ; beta-1 antibody; Gamma-aminobutyric acid (GABA) A receptor; subunit beta 1 antibody; Gamma-aminobutyric acid receptor subunit beta-1 antibody; GARB1 antibody; GBRB1_HUMAN antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat,Monkey

Immunogen

Synthesized peptide derived from Human GABAA Rβ1 around the phosphorylation site of S434.

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Form

Liquid

Tested Applications

WB, IHC, ELISA

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:100-1:300
ELISA	1:40000

Protocols

Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Related Products

Target Background

Function

Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.

Gene References into Functions

No allelic association was detected in this study between tested SNPs and risk for developing alcohol dependence in a British and Irish population; however, modest genotypic associations were found with several intronic GABRbeta1 SNPs that may directly influence alcohol dependence risk or may be in linkage disequilibrium with causal risk variants in nearby genes, including other GABA receptor subunits PMID: 28346242
Results from genome-wide DNA methylation, functional network analysis and pyrosequencing, show selective CpG sites (NOS1AP, BID, and GABRB1) differentially methylated in smokers and chronic obstructive pulmonary disease patients compared to nonsmokers. PMID: 28416970
PCDHB14- and GABRB1-like nervous system developmental genes are altered during early neuronal differentiation of NCCIT cells treated with ethanol PMID: 25566775
This study showed that in male group the expression of GABRB1 was generally lower in schizophrenia cases compared to the control, but was higher in female group. PMID: 25660468
Both mRNA and protein of GABAB receptor subunits, GABAB1 and GABAB2, were co-expressed in cultured human RPE cells; GABAB receptors regulate the [Ca2+]i via a pertussis toxin-sensitive Gi/o-protein pathway and a phospholipase C pathway PMID: 25241062
study provides the first evidence for the involvement of the GABRB1 gene in the thalamus structure and their interactive effects on intelligence PMID: 25192656
This study demonstrates altered patterns of N-glycosylation of GABRB1 in the temporal lobe in schizophrenia. PMID: 23917429
GABRB1 protein levels were significantly decreased in schizophrenia, major depressive disorder, and bipolar disorder patients' lateral cerebellum compared to controls. PMID: 24022508
These results suggest that epigenetic control of gene expression may affect the expression of GABRB1 and disrupt inhibitory synaptic transmission during embryonic development. PMID: 23392927
Gaba-A receptor subunit beta1 is not involved in amygdala hyperexcitability of patients with temporal lobe epilepsy. PMID: 20848605
Gaba (A) beta1 and beta3 subunit mRNA levels in the dorsolateral prefrontal cortex are not altered in schizophrenia. PMID: 20843900
linkage disequilibrium between beta frequency of EEG and a set of GABA(A) receptor genes PMID: 11891318
A signal for GABA A beta 1 isoform mRNA transcript could not be detected in the competitive RT-PCR assay. PMID: 15337300
histamine modulates heteromultimeric GABA(A) receptors and may thus represent an endogenous ligand for an allosteric site PMID: 18281286
three distinct sets of amino acid residues in the N-terminal extracellular domain of the hbeta1 subunit, which when mutated to the homologous residue in hbeta3 allow expression as a functional homomeric receptor PMID: 18650446

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Involvement in disease

Epileptic encephalopathy, early infantile, 45 (EIEE45)

Subcellular Location

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Protein Families

Ligand-gated ion channel (TC 1.A.9) family, Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily, GABRB1 sub-subfamily

Database Links

HGNC: 4081

OMIM: 137190

KEGG: hsa:2560

STRING: 9606.ENSP00000295454

UniGene: Hs.254117

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