GBP2 Antibody

Code CSB-PA009298LA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA009298LA01HU at dilution of 1:100
  • Immunofluorescent analysis of HepG2 cells using CSB-PA009298LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) GBP2 Polyclonal antibody
Uniprot No.
Target Names
GBP2
Alternative Names
GBP2Guanylate-binding protein 2 antibody; EC 3.6.5.- antibody; GTP-binding protein 2 antibody; GBP-2 antibody; HuGBP-2 antibody; Guanine nucleotide-binding protein 2 antibody; Interferon-induced guanylate-binding protein 2 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Guanylate-binding protein 2 protein (100-259AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The GBP2 Antibody (Product code: CSB-PA009298LA01HU) is Non-conjugated. For GBP2 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA009298LB01HU GBP2 Antibody, HRP conjugated ELISA
FITC CSB-PA009298LC01HU GBP2 Antibody, FITC conjugated
Biotin CSB-PA009298LD01HU GBP2 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA,IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Description

CUSABIO uses a peptide corresponding to amino acids 100-259 of the human GBP2 protein to immunize the rabbit to produce the anti-GBP2 antibody. This GBP2 polyclonal antibody exists as an unconjugated IgG isoform. It is reactive to human and mouse GBP2 protein. The GBP2 protein is an interferon-γ (IFN-γ)-induced GTPase that converts GTP to GDP and GMP. GBP2 also acts as a controlling factor for the proliferation and spreading of breast cancer cells. The high expression of GBP2 is related to a better prognosis of breast cancer. The purity of this antibody is over 95% using protein G purified. And it has been validated for use in ELISA, WB, IHC, and IF applications.

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Target Background

Function
Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions, but the major reaction product is GDP. Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes.
Gene References into Functions
  1. Study presents the first demonstration that GBP2 inhibits mitochondrial fission and cell metastasis in breast cancer cells both in vitro and in vivo. PMID: 29072687
  2. Low GBP2 expression is associated with metastasis in breast cancer. PMID: 23001506
  3. Downregulation of MIR-433 is associated with myeloproliferative neoplasms. PMID: 22864358
  4. The in vivo localization of GBP-2 at cellular membranes is regulated by isoprenylation and dimerization. PMID: 21151871
  5. Guanylate-binding protein 2 mRNA in peripheral blood leukocytes may have a role in acute cellular rejection after liver transplantation PMID: 19912588
  6. Sky1p utilizes the same docking groove to bind yeast SR-like protein Gbp2p and phosphorylates all three serines present in a contiguous RS dipeptide stretch PMID: 17517895
  7. GBP-2 is regulated by p53 and may have a role in esophageal squamous cell carcinomas PMID: 19003964

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Subcellular Location
Cytoplasm. Cytoplasm, perinuclear region. Golgi apparatus membrane. Membrane; Lipid-anchor.
Protein Families
TRAFAC class dynamin-like GTPase superfamily, GB1/RHD3-type GTPase family, GB1 subfamily
Database Links

HGNC: 4183

OMIM: 600412

KEGG: hsa:2634

STRING: 9606.ENSP00000359497

UniGene: Hs.386567

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