GBP5 Antibody

Code CSB-PA009301GA01HU
Size US$685
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Product Details

Uniprot No. Q96PP8
Target Names GBP5
Alternative Names GBP 5 antibody; GBP TA antigen antibody; GBP-5 antibody; GBP-TA antigen antibody; GBP5 antibody; GBP5_HUMAN antibody; GTP binding protein 5 antibody; GTP-binding protein 5 antibody; Guanine nucleotide binding protein 5 antibody; Guanine nucleotide-binding protein 5 antibody; Guanylate binding protein 5 antibody; Guanylate-binding protein 5 antibody; UNQ2427/PRO4987 antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Human GBP5
Immunogen Species Homo sapiens (Human)
Isotype IgG
Purification Method Antigen Affinity Purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications ELISA,WB,IHC,IF
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
(From Uniprot)
As an activator of NLRP3 inflammasome assembly, plays a role in innate immunity and inflammation. Promotes selective NLRP3 inflammasome assembly in response to microbial and soluble, but not crystalline, agents
Gene References into Functions
  1. GBP5 and KLF2 may be useful as a diagnostic tool for active tuberculosis, also the two-gene set may serve as surrogate biomarkers for monitoring tuberculosis therapy. PMID: 28941629
  2. these results reveal that GBP5 inhibited influenza virus replication through the activation of IFN signaling and proinflammatory factors PMID: 28376501
  3. Previously reported tetrameric and dimeric species of hGBP-1 and hGBP-5 were unmasked as dimers and monomers, respectively, with their shapes depending on both the bound nucleotide and the ionic strength of the solution. PMID: 28580591
  4. Antiviral activity requires Golgi localization of GBP5, but not its GTPase activity. PMID: 26996307
  5. GZMA, GBP5 and CD64 genes show promise as a rapid diagnostic markers separating tuberculosis from other pulmonary diseases. PMID: 26025597
  6. The in vivo localization of GBP-5 at the Golgi apparatus is regulated by isoprenylation and dimerization. PMID: 21151871
  7. analysis of guanylate binding protein 5 and a tumor-specific truncated splice variant PMID: 20180847
  8. Eight of nine melanoma cell lines expressed GBP-5a/b and four of nine additionally low levels of GBP-5ta. PMID: 15175044
  9. 3 genes were upregulated in patients with chronic EBV infection: guanylate binding protein 1, tumor necrosis factor-induced protein 6, and guanylate binding protein 5; they may be associated with the inflammatory reaction or with cell proliferation. PMID: 18260761
  10. GBP5 is constitutively localized in the Golgi apparatus of endothelial cells. PMID: 17266443

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Subcellular Location Cytoplasm, Golgi apparatus membrane, Lipid-anchor
Protein Families TRAFAC class dynamin-like GTPase superfamily, GB1/RHD3-type GTPase family, GB1 subfamily
Tissue Specificity Expressed in peripheral blood monocytes (at protein level).
Database Links

HGNC: 19895

OMIM: 611467

KEGG: hsa:115362

STRING: 9606.ENSP00000340396

UniGene: Hs.513726

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