GEM Antibody

Datasheet

Code	CSB-PA009362GA01HU
Size	$600
	Order now
Have Questions?	Leave a Message or Start an on-line Chat

Product Details
Related Products
Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

P55040

Target Names

GEM

Alternative Names

GEM antibody; KIRGTP-binding protein GEM antibody; GTP-binding mitogen-induced T-cell protein antibody; RAS-like protein KIR antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Human GEM

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

■ Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function

Could be a regulatory protein, possibly participating in receptor-mediated signal transduction at the plasma membrane. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity.

Gene References into Functions

Down regulation of Gem expression was involved in the pathogenesis of hepatocellular carcinoma (HCC), and it might be a favorable independent prognostic parameter for HCC. PMID: 25155751
These findings demonstrate a new role of Gem/Gmip/RhoA signaling in cortical actin regulation during early mitotic stages. PMID: 25173885
Gem is involved both in T-cell spontaneous cell migration as well as chemotaxis and plays an important role in cell-to-cell HTLV-1 viral transmission. PMID: 24586148
Data show a mechanism by which GTPase Gem contributes to the mitotic progression by maintaining correct spindle length through the kinesin Kif9. PMID: 22964304
Gem contains two candidate inhibitory sites, each capable of producing full inhibition of P/Q-type Ca(2+) channels. PMID: 22589533
GEM plays a key role during C. pneumoniae entry into human cells. PMID: 20233927
We discuss the structural and functional properties of RGK proteins and highlight recent work addressing the mechanism of Gem regulation by calmodulin and 14-3-3. PMID: 16242932
crystallographic structure and biochemical characterization indicate that Gem G-domain markedly prefers GDP over GTP PMID: 17052716
Gem is a bona fide GTPase that exhibits striking structural and biochemical features that should impact its regulation and cellular activities PMID: 17107948

Hide All

Subcellular Location

Cell membrane; Peripheral membrane protein; Cytoplasmic side.

Protein Families

Small GTPase superfamily, RGK family

Tissue Specificity

Most abundant in thymus, spleen, kidney, lung, and testis. Less abundant in heart, brain, liver and skeletal muscle.

Database Links

HGNC: 4234

OMIM: 600164

KEGG: hsa:2669

STRING: 9606.ENSP00000297596

UniGene: Hs.654463

Promotions

Transmembrane Protein Questionnaire with Gifts

Email: [email protected]
Distributors Worldwide

Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Oncogenes and Cancer Claudin 18.2, is a 'Dark Horse' in Anti-tumour Therapy? Decoding the Biological Complexity of Endometrial Cancer: Essential Insights for Researchers Multiple Myeloma, One of High-Risk Factors for COVID-19 STAT3: a Key Transcriptional Regulator in Cancer TNFRSF9: A Potent Immune-Stimulator in Cancer Cross-reactivity of Antibody: Beneficial or Harmful? NRG1: an Intriguing Therapeutic Target in Diseases Cellular Senescence and Its Markers TPBG/5T4: the Oncofetal Protein, an Appealing Target for ADC or Vaccine Therapeutics in Tumors! CD93, A Rising Star in Anti-Tumor Therapy With the High Potential in Cancer Immunotherapy, CD40 Is Triggering Attention CD31- A Complex Function Molecule CD73, What a Powerful Therapy Target in Tumor Immune CLDN4: A Potential Prognostic Indicator and Therapeutic Target in Tumors！ TFR1 (TFRC): a Stimulator of Fe Transport Affects Anemia, Neurodegenerative Disorders and Cancers! Categories over 10000! --Rare diseases that are no longer SLC7A11: a New Potential Therapeutic Target via Induced Ferroptosis in Tumors! The Overview of Fc Receptors- Classification, Related Signaling Pathways and Application DSG2: a Vital Member of Desmosomal Cadherin Family, an Exciting New Target for Cardiomyopathy, Adenovirus, and Tumors! Glial Fibrillary Acidic Protein - Astrocyte Specific Marker ZG16B: A New Tumor Biomarker Offers Important Insights for Drug Development in Pancreatic Cancer! CEACAM8: a Member of CEA Family, Emerging as a Vital Player in Gynaecological or Gastrointestinal Cancer Research! CEACAM5: A Promising Member of CEACAM Family, A Potential Target for ADC Drug Research! CD147, a New Target of SARS-CoV-2 Invasion DKK1: a Well-Characterized Wnt Inhibitor, a Multifunctional Regulator in Multiple Cancers! A "trembling" Parkinson's Disease The Overview of Coagulation VSIG4: a Prominent B7 Family Costimulatory Molecule or Complement Receptor in Cancers and Inflammatory Diseases! Monoclonal Antibody Drugs Overview What You Have To Know about Lung Cancer Exploring Neurodegeneration: A Comprehensive Guide for Researchers How to Measure Histone Modification? CD48: An Emerging Human Immune Co-stimulatory Molecule, Friend or Foe? About Thyroid Tumor, This Information You Must Know! What A Paradoxical TNF Signaling Pathway-Based on Different Receptors What Essential Biological Knowledge is Needed for Hepatocellular Carcinoma Research? What Are the Effects of Abnormalities in the ALK Gene These Tumor Databases You Have To Know CD146, A Powerful Tumor Marker Introduction of Hepatocellular Carcinoma Related Signaling Pathways Diabetes: What You Need to Know Before Starting Research? CRTAM: Class I Restricted T cell-associated Molecule, an Intriguing New Member of the Ig-SF Family! TMPRSS2, an Activator for SARS-CoV-2 Invasion An Overview of CD226 and Its Promising Role in Cancer Immunotherapy TM4SF1: a Member of the Transmembrane-4-Superfamily (L6), a New Vascular Therapeutic Target? LY6G6D (LY6-G): A New Member of Lymphocyte Antigen-6 Family Holds Big Opportunities in Bispecific Antibody for CRC Treatment! Applications of recombinant proteins The Overview of Colony Stimulating Factors The Memory thief - Alzheimer's disease The Overview of Growth Factor Tumor Necrosis Factor (TNF) The Overview of Interferon Tumor markers A Group of Promising Proteins - Cell Cycle Markers The Overview of Phage Display：Protocol, Classification, Application and FAQs CDCP1: A Key Mediator for Cell Signaling in Cancers, an Emerging Target for Anti-Tumor Drugs! The overview of Wnt signaling pathway Chemokine Receptor CCR6: the Specific Receptor for CCL20, a Potential Target for Drug Research in Inflammatory Diseases and Gastrointestinal Cancer! CEACAM6: a Potent CEA Family Molecule, a New Tumor Marker or Anti-Cancer Target! IGFL1: A Novel Secretory Protein of IGF-Like Family Presents a High Cancer-Promoting Potential! CNR1 (CB1): A Crucial Receptor of Endocannabinoid System Offers Potential Treatments for Tumors and Glycolipid Metabolism Disorders! DSG3: An Emerging Tumor-Associated Adhesion Factor, a Specific Marker for the Clinical Diagnosis of Pemphigus Vulgaris (PV)! MAGEA4: a Member of the Melanoma-Associated Antigen (MAGE) Family, a Popular Target for Tumor-Specific Immune Research! In Vivo vs. In Vitro: Choosing the Right Experimental Model for Your Research IL-6: an Important Participant in the Inflammatory Cascade, One of the Most Functional Cytokines in Various Diseases Research! Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

Join us with

Subscribe newsletter

Leave a message

Message

Product >> Product Name：
Product >> Code：
Name： *
Email： *
Company/Organization：
Phone：
Since emails may get flagged by spam filters occasionally, we recommend leaving your phone number as a precaution. Your information is safe with us.
Question/Comment： *
Your Region： *
I'd like to receive email newsletters from Cusabio

Yes

No
How do you know CUSABIO?

Email

Distributor

Search engine

Advertisement

Others
CAPTCHA verification：

Place an order now

I. Product details

Product name *

Code *

Size *

Quantity *

Message

II. Contact details

Name *

Email address *

Company/Organization

Phone

III. Ship To

Address *

City *

State/Province *

Zip/Post code *

Country *

Attn Name *

Phone# *

IV. Bill To Same as Shipping Address