GEM Antibody

Code CSB-PA009362ESR2HU
Size US$166
Order now
Image
  • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA009362ESR2HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA009362ESR2HU at dilution of 1:100

Have Questions? Leave a Message or Start an on-line Chat

Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) GEM Polyclonal antibody
Uniprot No.
Target Names
GEM
Alternative Names
GEM antibody; KIRGTP-binding protein GEM antibody; GTP-binding mitogen-induced T-cell protein antibody; RAS-like protein KIR antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human GTP-binding protein GEM protein (1-150AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function
Could be a regulatory protein, possibly participating in receptor-mediated signal transduction at the plasma membrane. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity.
Gene References into Functions
  1. Down regulation of Gem expression was involved in the pathogenesis of hepatocellular carcinoma (HCC), and it might be a favorable independent prognostic parameter for HCC. PMID: 25155751
  2. These findings demonstrate a new role of Gem/Gmip/RhoA signaling in cortical actin regulation during early mitotic stages. PMID: 25173885
  3. Gem is involved both in T-cell spontaneous cell migration as well as chemotaxis and plays an important role in cell-to-cell HTLV-1 viral transmission. PMID: 24586148
  4. Data show a mechanism by which GTPase Gem contributes to the mitotic progression by maintaining correct spindle length through the kinesin Kif9. PMID: 22964304
  5. Gem contains two candidate inhibitory sites, each capable of producing full inhibition of P/Q-type Ca(2+) channels. PMID: 22589533
  6. GEM plays a key role during C. pneumoniae entry into human cells. PMID: 20233927
  7. We discuss the structural and functional properties of RGK proteins and highlight recent work addressing the mechanism of Gem regulation by calmodulin and 14-3-3. PMID: 16242932
  8. crystallographic structure and biochemical characterization indicate that Gem G-domain markedly prefers GDP over GTP PMID: 17052716
  9. Gem is a bona fide GTPase that exhibits striking structural and biochemical features that should impact its regulation and cellular activities PMID: 17107948

Show More

Hide All

Subcellular Location
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein Families
Small GTPase superfamily, RGK family
Tissue Specificity
Most abundant in thymus, spleen, kidney, lung, and testis. Less abundant in heart, brain, liver and skeletal muscle.
Database Links

HGNC: 4234

OMIM: 600164

KEGG: hsa:2669

STRING: 9606.ENSP00000297596

UniGene: Hs.654463

CUSABIO guaranteed quality
icon of phone
Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
icon of address
Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
icon of social media
Join us with

Subscribe newsletter

Leave a message

* To protect against spam, please pass the CAPTCHA test below.
CAPTCHA verification
© 2007-2024 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1
webinars: DT3C facilitates antibody internalization X
Place an order now

I. Product details

*
*
*
*

II. Contact details

*
*

III. Ship To

*
*
*
*
*
*
*

IV. Bill To

*
*
*
*
*
*
*
*