GFRA1 Antibody

Code CSB-PA008804
Size US$100
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Product Details

Uniprot No.
Target Names
GFRA1
Alternative Names
GDNF family receptor alpha 1 antibody; GDNF family receptor alpha-1 antibody; GDNF R antibody; GDNF RA antibody; GDNF receptor alpha antibody; GDNF receptor alpha-1 antibody; GDNFR alpha 1 antibody; GDNFR alpha antibody; GDNFR antibody; GDNFR-alpha-1 antibody; GDNFRA antibody; GDNFRalpha antibody; GFR alpha 1 antibody; GFR alpha1 antibody; GFR-alpha-1 antibody; GFRA 1 antibody; Gfra1 antibody; GFRA1_HUMAN antibody; GFRalpha1 antibody; Glial cell line derived neurotrophic factor receptor alpha antibody; GPI linked anchor protein antibody; MGC23045 antibody; PI linked cell surface accessory protein antibody; RET 1L antibody; RET ligand 1 antibody; RET1L antibody; RETL 1 antibody; RETL1 antibody; TGF beta related neurotrophic factor receptor 1 antibody; TGF-beta-related neurotrophic factor receptor 1 antibody; TRNR 1 antibody; TRNR1 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthesized peptide derived from the Internal region of Human GFRα-1.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
IHC, ELISA
Recommended Dilution
Application Recommended Dilution
IHC 1:100-1:300
ELISA 1:10000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor.
Gene References into Functions
  1. circGFRA1 may function as a competing endogenous RNA (ceRNA) to regulate GFRA1 expression through sponging miR-34a to exert regulatory functions in TNBC. PMID: 29037220
  2. the methylation status of CpG sites in GFRA1 and GSTM2 may have a role and could be used as potential biomarkers for the screening of rectal cancer PMID: 27566576
  3. GFRA1 regulates AMPK-dependent autophagy by promoting SRC phosphorylation independent of proto-oncogene RET kinase PMID: 27754745
  4. that the consequences of this is that GFRalpha-1-mediated signalling is altered during the ageing process PMID: 27346872
  5. RET c.1296A may be a common susceptibility allele for nephron underdosing-related diseases. The 5'-UTR and intronic variants near exon 5 of GFRA1 are not associated with nephron endowment. PMID: 27533506
  6. Hox proteins coordinate motor neuron differentiation and connectivity programs through Ret/Gfra genes. PMID: 26904955
  7. This study demonstrate, using a knock-in mouse model in which GFRalpha1 is no longer located in lipid rafts, that the developmental functions of GDNF in the periphery require the translocation of the GDNF receptor complex into lipid rafts. PMID: 26400951
  8. Methylation changes of GFRA1, SRF, and ZNF382 may be a potential biomarker set for prediction of gastric carcinoma metastasis. PMID: 25009298
  9. GFRalpha1 levels in neurons from autopsied AD brains are significantly decreased. PMID: 25253858
  10. In the cochlea, GFRalpha-1 was identified mainly in the cell bodies of the spiral neurons. In the organ of Corti, GFRalpha-1 was demonstrated in the Deiters' cells, Hensen cells, inner pillar cells, and weakly in inner hair cells but not in the outer hair cells. PMID: 24139947
  11. The study shows co-localization of RET with GFRA1 and GFRA2 in myenteric ganglia of the adult human colon. PMID: 23881409
  12. The expression of GFRalpha1 and/or GFRalpha3, especially when combined with ARTN expression, may be useful predictors of disease progression and outcome in specific subtypes of mammary carcinoma. PMID: 23351331
  13. Mutations in GFRA1 gene is associated with urinary tract malformations. PMID: 22729463
  14. Post-synaptic transgenic GFRalpha1 has profound effects on the development of dopamine neurons, resulting in a 40% increase in the adult number. PMID: 21133924
  15. This study found nominally-significant evidence for interactions between GFRA1, 2 and 3 associated with schizophrenia and clozapine response, consistent with the locations of these three genes within linkage regions for schizophrenia. PMID: 20116071
  16. Results identify persephin, a GDNF family member, as a novel ligand for GFRalpha1/RET receptor complex. PMID: 20350599
  17. MEN2 arises from activating missense mutations in RET, causing autodimerization under certain conditions. The position of missense mutations influences medullary thyroid carcinoma aggressiveness. Review. PMID: 20669561
  18. Here we report that human nigral dopaminergic neurons express GFRalpha1 and RET receptors at all ages. There was no reduction in the number of neurons expressing these receptors as a function of age. PMID: 20347960
  19. GFR-alpha1 mRNA transcripts were detected in oocytes and GCs from all samples from fetuses, girls and adult women. PMID: 19896648
  20. The expression of GFRA1 in normal infants and normoganglionic colon of patients with Hirschsprung's disease was restricted to receptor tyrosine kinase(RET)-negative glial cells and RET-positive neurons of the ganglionic plexus. PMID: 12065680
  21. GFRA1-193C > G and 537T > C could be in linkage disequilibrium with other loci responsible for medullary thyroid cancer PMID: 12490080
  22. analysis of binding surface for the GDNF-GFR alpha 1 PMID: 14514671
  23. GFRalpha-1 were observed within sensory and motor nuclei of cranial nerves, dorsal column nuclei, olivary nuclear complex, reticular formation, pontine nuclei, locus caeruleus, raphe nuclei, substantia nigra, and quadrigeminal plate. PMID: 17825269
  24. GDNF can act as an important component of the inflammatory response in breast cancers and its effects aare mediated by GFR alpha 1 receptors. PMID: 18089803
  25. GDNF is a key component to preserve several cell populations in the nervous system and also participates in the survival and differentiation of peripheral neurons. PMID: 18394855
  26. 38 cases of germ cell tumors: 26 cases contained immature teratoma, of which 24 had immature neuroepithelium and showed strong membrane staining for GFRalpha-1. staining for GFRalpha-1 in immature neuroepithelium may facilitate its identification. PMID: 19019765

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Subcellular Location
Cell membrane; Lipid-anchor, GPI-anchor. Golgi apparatus, trans-Golgi network. Endosome. Endosome, multivesicular body.
Protein Families
GDNFR family
Database Links

HGNC: 4243

OMIM: 601496

KEGG: hsa:2674

STRING: 9606.ENSP00000393725

UniGene: Hs.388347

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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