GFRA1 Antibody

Datasheet
Code CSB-PA449746
Former Code(s) CSB-PA160092,CSB-PA216478
Size US$299
Uniprot No. P56159
Image
  • Gel: 10%SDS-PAGE, Lysate: 30 μg, Lane: 293T cells, Primary antibody: CSB-PA449746(GFRA1 Antibody) at dilution 1/1250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunogen Synthetic peptide of Human GFRA1
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Tested Applications ELISA,WB;ELISA:1:1000-1:10000,WB:1:1000-1:3000
Relevance Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Multiple alternatively spliced transcript variants have been described for this gene.
Form Liquid
Conjugate Non-conjugated
Storage Buffer -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method Antigen affinity purification
Isotype IgG
Alias GDNF family receptor alpha 1
Immunogen Species Homo sapiens (Human)
Target Names GFRA1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor (By similarity).
Subcellular Location Cell membrane, Lipid-anchor, GPI-anchor
Protein Families GDNFR family
Database Links

HGNC: 4243

OMIM: 601496

KEGG: hsa:2674

STRING: 9606.ENSP00000393725

UniGene: Hs.388347

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