GFRA2 Antibody

Code CSB-PA009380GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
GFRA2
Alternative Names
GDNF family receptor alpha 2 antibody; GDNF family receptor alpha-2 antibody; GDNF receptor alpha-2 antibody; GDNF receptor beta antibody; GDNFR beta antibody; GDNFR-alpha-2 antibody; GDNFR-beta antibody; GDNFRB antibody; GFR alpha 2 antibody; GFR-alpha-2 antibody; GFRA 2 antibody; Gfra2 antibody; GFRA2_HUMAN antibody; Glial cell line derived neurotrophic factor family receptor alpha2b antibody; Glial cell line derived neurotrophic factor receptor beta antibody; Neurturin receptor alpha antibody; NRTNR alpha antibody; NRTNR-alpha antibody; NTNR alpha antibody; NTNR-alpha antibody; NTNRA antibody; PI linked cell surface accessory protein antibody; PI linked cell-surface accessory protein antibody; RET ligand 2 antibody; RETL 2 antibody; RETL2 antibody; TGF beta related neurotrophic factor receptor 2 antibody; TGF-beta-related neurotrophic factor receptor 2 antibody; TRN receptor GPI anchored antibody; TRNR 2 antibody; TRNR2 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human GFRA2
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
0.1M NaHCO3,0.1M Glycine, 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor.; participates in NRTN-induced 'Ser-727' phosphorylation of STAT3.
Gene References into Functions
  1. biophysical results show that the relative concentration of GFRa2 on cell surfaces can affect the functional affinity of NRTN through avidity effects. PMID: 29414779
  2. The cardiac GFRA2 signaling pathway is distinct from the canonical pathway dependent on the RET tyrosine kinase. PMID: 27396331
  3. High GFRalpha2 expression level leads to PTEN inactivation via Mir-17-5p up-regulation, promoting pancreatic tumor cell growth and chemoresistance. PMID: 27400681
  4. GFRA2 variants associated with diabetic neuropathic pain. PMID: 24974787
  5. GFRalpha2 is under-expressed in functioning adenomas and over-expressed in non-functioning adenomas, specifically gonadotropinomas PMID: 24402129
  6. In the cochlea, immunolabeling for GFRalpha-2 receptors was identified mainly in the cell bodies of the spiral neurons than in the nerve fibers. No structures in the organ of Corti were labeled with GFRalpha-2 receptor antibody PMID: 24139947
  7. GFRalpha-2 is associated with severe abdominal pain sensation in pancreatic cancer patients. PMID: 24067900
  8. Cyclic AMP signalling through PKA but not Epac is essential for neurturin-induced biphasic ERK1/2 activation and neurite outgrowths through GFRalpha2 isoforms. PMID: 21723942
  9. GFRA2 genetic variants, and age, may play a role in susceptibility to tardive dyskinesia. PMID: 20369355
  10. Both GFR alpha2a and GFR alpha2c, but not GFR alpha2b, promote neurite outgrowth in transfected Neuro2A cells. PMID: 17522305
  11. GFRalpha-2 were observed within sensory and motor nuclei of cranial nerves, dorsal column nuclei, olivary nuclear complex, reticular formation, pontine nuclei, locus caeruleus, raphe nuclei, substantia nigra, and quadrigeminal plate. PMID: 17825269

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Subcellular Location
Cell membrane; Lipid-anchor, GPI-anchor.
Protein Families
GDNFR family
Tissue Specificity
Isoform 1 is found in both brain and placenta.
Database Links

HGNC: 4244

OMIM: 601956

KEGG: hsa:2675

STRING: 9606.ENSP00000428518

UniGene: Hs.441202

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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