GINS1 Antibody

Datasheet

Citations (1)

Code	CSB-PA617926LA01HU
Size	US$166
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Image	IHC image of CSB-PA617926LA01HU diluted at 1:400 and staining in paraffin-embedded human prostate tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. IHC image of CSB-PA617926LA01HU diluted at 1:400 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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Product Details
Citations
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Customer Reviews and Q&A
Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) GINS1 Polyclonal antibody

Uniprot No.

Q14691

Target Names

GINS1

Alternative Names

DNA replication complex GINS protein PSF1 antibody; GINS complex subunit 1 (Psf1 homolog) antibody; GINS complex subunit 1 antibody; GINS1 antibody; partner of sld five-1 antibody; partner of sld5 antibody; PSF1 homolog antibody; PSF1_HUMAN antibody; RP4-691N24.2 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human DNA replication complex GINS protein PSF1 protein (1-196AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The GINS1 Antibody (Product code: CSB-PA617926LA01HU) is Non-conjugated. For GINS1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA617926LB01HU	GINS1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA617926LC01HU	GINS1 Antibody, FITC conjugated
Biotin	CSB-PA617926LD01HU	GINS1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:200-1:500

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Citations

Construction of a circular RNA–microRNA–messenger RNA regulatory network of hsa_circ_0043256 in lung cancer by integrated analysis Yongwen Li,Thoracic cancer,2021

Customer Reviews and Q&A

■ Customer Reviews

Average Rating:

5.0 - 1 reviews

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Applications : immunohistochemistry

Sample type: cells

Review: Validation of hub genes in the translational level using immunohistochemistry, including BIRC5, SHCBP1, CCNA2, SKA3, GINS1.

By Anonymous

Target Background

Function

Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.

Gene References into Functions

The authors show that GINS is a compact tetramer in solution as observed in crystal structures, but also forms a double-tetrameric population, detectable by electron microscopy. PMID: 28071757
Autosomal recessive, partial GINS1 deficiency impairs DNA replication and underlies intra-uterine (and postnatal) growth retardation, chronic neutropenia, and NK cell deficiency. PMID: 28414293
PSF1 mRNA expression was an independent factor associated with prognosis of colorectal cancer. PMID: 21713706
These results suggest that PSF1 over-expression is specifically involved in breast cancer cell growth. PMID: 20825491
Findings implicate PSF1 in tumorigenesis and offer initial evidence of its potential as a theranostic target. PMID: 20103637
expression of mammalian GINS is regulated by 17beta-Estradiol-stimulated estrogen receptor alpha, and PSF3 acts as a gene responsive to transcription factor E2F1 PMID: 17127213
the C-terminal domain of Psf1 does not contribute to the stability of the GINS complex but is crucial for chromatin binding and replication activity PMID: 17417653

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Subcellular Location

Nucleus. Chromosome.

Protein Families

GINS1/PSF1 family

Database Links

HGNC: 28980

OMIM: 610608

KEGG: hsa:9837

STRING: 9606.ENSP00000262460

UniGene: Hs.658464

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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