GINS1 Antibody

Code CSB-PA617926LA01HU
Size US$299Purchase it in Cusabio online store
(only available for customers from the US)
Image
  • IHC image of CSB-PA617926LA01HU diluted at 1:400 and staining in paraffin-embedded human prostate tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

  • IHC image of CSB-PA617926LA01HU diluted at 1:400 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) GINS1 Polyclonal antibody
Uniprot No. Q14691
Target Names GINS1
Alternative Names DNA replication complex GINS protein PSF1 antibody; GINS complex subunit 1 (Psf1 homolog) antibody; GINS complex subunit 1 antibody; GINS1 antibody; partner of sld five-1 antibody; partner of sld5 antibody; PSF1 homolog antibody; PSF1_HUMAN antibody; RP4-691N24.2 antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human DNA replication complex GINS protein PSF1 protein (1-196AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:200-1:500
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Applications : immunohistochemistry

Sample type: cells

Review: Validation of hub genes in the translational level using immunohistochemistry, including BIRC5, SHCBP1, CCNA2, SKA3, GINS1.

By Anonymous

Target Background

Function
(From Uniprot)
Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.
Gene References into Functions
  1. The authors show that GINS is a compact tetramer in solution as observed in crystal structures, but also forms a double-tetrameric population, detectable by electron microscopy. PMID: 28071757
  2. Autosomal recessive, partial GINS1 deficiency impairs DNA replication and underlies intra-uterine (and postnatal) growth retardation, chronic neutropenia, and NK cell deficiency. PMID: 28414293
  3. PSF1 mRNA expression was an independent factor associated with prognosis of colorectal cancer. PMID: 21713706
  4. These results suggest that PSF1 over-expression is specifically involved in breast cancer cell growth. PMID: 20825491
  5. Findings implicate PSF1 in tumorigenesis and offer initial evidence of its potential as a theranostic target. PMID: 20103637
  6. expression of mammalian GINS is regulated by 17beta-Estradiol-stimulated estrogen receptor alpha, and PSF3 acts as a gene responsive to transcription factor E2F1 PMID: 17127213
  7. the C-terminal domain of Psf1 does not contribute to the stability of the GINS complex but is crucial for chromatin binding and replication activity PMID: 17417653

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Subcellular Location Nucleus. Chromosome.
Protein Families GINS1/PSF1 family
Database Links

HGNC: 28980

OMIM: 610608

KEGG: hsa:9837

STRING: 9606.ENSP00000262460

UniGene: Hs.658464

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