GINS1 Antibody, Biotin conjugated

Code CSB-PA617926LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) GINS1 Polyclonal antibody
Uniprot No.
Target Names
GINS1
Alternative Names
DNA replication complex GINS protein PSF1 antibody; GINS complex subunit 1 (Psf1 homolog) antibody; GINS complex subunit 1 antibody; GINS1 antibody; partner of sld five-1 antibody; partner of sld5 antibody; PSF1 homolog antibody; PSF1_HUMAN antibody; RP4-691N24.2 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human DNA replication complex GINS protein PSF1 protein (1-196AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.
Gene References into Functions
  1. The authors show that GINS is a compact tetramer in solution as observed in crystal structures, but also forms a double-tetrameric population, detectable by electron microscopy. PMID: 28071757
  2. Autosomal recessive, partial GINS1 deficiency impairs DNA replication and underlies intra-uterine (and postnatal) growth retardation, chronic neutropenia, and NK cell deficiency. PMID: 28414293
  3. PSF1 mRNA expression was an independent factor associated with prognosis of colorectal cancer. PMID: 21713706
  4. These results suggest that PSF1 over-expression is specifically involved in breast cancer cell growth. PMID: 20825491
  5. Findings implicate PSF1 in tumorigenesis and offer initial evidence of its potential as a theranostic target. PMID: 20103637
  6. expression of mammalian GINS is regulated by 17beta-Estradiol-stimulated estrogen receptor alpha, and PSF3 acts as a gene responsive to transcription factor E2F1 PMID: 17127213
  7. the C-terminal domain of Psf1 does not contribute to the stability of the GINS complex but is crucial for chromatin binding and replication activity PMID: 17417653

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Subcellular Location
Nucleus. Chromosome.
Protein Families
GINS1/PSF1 family
Database Links

HGNC: 28980

OMIM: 610608

KEGG: hsa:9837

STRING: 9606.ENSP00000262460

UniGene: Hs.658464

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