GINS1 Antibody, Biotin conjugated

1. The authors show that GINS is a compact tetramer in solution as observed in crystal structures, but also forms a double-tetrameric population, detectable by electron microscopy. PMID: 28071757
2. Autosomal recessive, partial GINS1 deficiency impairs DNA replication and underlies intra-uterine (and postnatal) growth retardation, chronic neutropenia, and NK cell deficiency. PMID: 28414293
3. PSF1 mRNA expression was an independent factor associated with prognosis of colorectal cancer. PMID: 21713706
4. These results suggest that PSF1 over-expression is specifically involved in breast cancer cell growth. PMID: 20825491
5. Findings implicate PSF1 in tumorigenesis and offer initial evidence of its potential as a theranostic target. PMID: 20103637
6. expression of mammalian GINS is regulated by 17beta-Estradiol-stimulated estrogen receptor alpha, and PSF3 acts as a gene responsive to transcription factor E2F1 PMID: 17127213
7. the C-terminal domain of Psf1 does not contribute to the stability of the GINS complex but is crucial for chromatin binding and replication activity PMID: 17417653

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HGNC: 28980

OMIM: 610608

KEGG: hsa:9837

STRING: 9606.ENSP00000262460

UniGene: Hs.658464