GNA13 Antibody

Code CSB-PA009585GA01HU
Size US$685
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Product Details

Uniprot No. Q14344
Target Names GNA13
Alternative Names G alpha 13 antibody; G alpha-13 antibody; G-protein subunit alpha-13 antibody; GNA13 antibody; GNA13_HUMAN antibody; Guanine nucleotide binding protein (G protein) alpha 13 antibody; Guanine nucleotide binding protein alpha 13 subunit antibody; Guanine nucleotide-binding protein subunit alpha-13 antibody
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Immunogen Human GNA13
Immunogen Species Homo sapiens (Human)
Isotype IgG
Purification Method Antigen Affinity purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications ELISA,WB
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems
Gene References into Functions
  1. High expression of GNA13 is associated with hepatocellular carcinoma. PMID: 27883022
  2. The ability of enhanced GNA13 signaling to suppress KLK gene expression appears at least in part due to the ability of enhanced GNA13 signaling to negatively impact Rho/ROCK-signaling. PMID: 27424208
  3. the selective expression of FZD10 in brain vascular endothelial cells points at a potential role of FZD10-Galpha13 signalling in central nervous system angiogenesis. PMID: 28126591
  4. The protein profile indicates attenuation of "GNA13-ERK signaling" in schizophrenia brain. In particular, EIF4G2 and CYFIP1, which are located downstream of the GNA13-ERK network, were decreased, suggesting that the attenuation of this signal network may cause impairment of axon formation and synapse plasticity in the brain of schizophrenia patients. PMID: 28214564
  5. Findings indicate a tumor suppressive role for G protein subunit alpha 13 (Galpha13) and rhoA GTP-binding protein (RhoA) in Burkitt's lymphoma and diffuse large B-cell lymphoma (DLBCL). PMID: 26616858
  6. Data (including data from studies using transgenic mice) suggest that R7BP-RGS7 heterotrimers interact with Galpha13 to augment signaling pathways in neurons that regulate neurite morphogenesis. (R7BP = RGS7 family binding protein; RGS7 = regulator of G-protein signaling 7 protein; Galpha13 = GTP-binding protein alpha subunit 13) PMID: 28432124
  7. Upregulation of GNA13 expression increased the proliferation and tumorigenicity of gastric cancer. PMID: 26735177
  8. Knockdown DDR1 reversed the effects of Galpha13 knockdown on cell-cell adhesion and proteolytic invasion in three-dimensional collagen. PMID: 26589794
  9. RGS22 acts as a tumor suppressor, repressing human pancreatic adenocarcinoma cell migration by coupling to GNA12/13. PMID: 26323264
  10. Galpha13 Switch Region 2 Binds to the Talin Head Domain and Activates alphaIIbbeta3 Integrin in Human Platelets PMID: 26292217
  11. GNA13 expression in breast cancer cells is regulated by post-transcriptional mechanisms involving miR-31. PMID: 25889182
  12. Data show that N-linked glycosylation of protease-activated receptor-1 (PAR1) at extracellular loop 2 (ECL2) controls G12/13 versus Gq G-proteins coupling specificity in response to thrombin stimulation. PMID: 26100877
  13. Our findings highlight the important role of miR-29c in regulating CRC EMT via GSK-3b/b-catenin signaling by targeting GNA13 and PTP4A and provide new insights into the metastatic basis of colorectal cancer PMID: 25193986
  14. These results place Blk upstream of the p190RhoGAP-RhoA pathway in Galpha13-activated cells, overall representing an opposing signaling module during CXCL12-triggered invasion. PMID: 25025568
  15. findings identify a Galpha13-dependent pathway that exerts dual actions in suppressing growth and blocking dissemination of germinal centre B cells that is frequently disrupted in germinal centre B-cell-derived lymphoma PMID: 25274307
  16. Findings indicate lysophosphatidic acid (LPA)-lysophosphatidic acid receptor-Galpha13 signaling node as a therapeutic target for pancreatic cancer treatment and control. PMID: 23508014
  17. Mutation in the Galpha13 gene is associated with diffuse large B-cell lymphoma. PMID: 23699601
  18. Itk enhances Galpha13 mediated activation of serum response factor (SRF) transcriptional activity dependent on its ability to interact with Galpha13, but its kinase activity is not required to enhance SRF activity. PMID: 23454662
  19. GNA13 is an important mediator of prostate cancer cell invasion, and miR-182 and miR-200 family members regulate its expression post-transcriptionally PMID: 23329838
  20. Activation of p115-RhoGEF requires direct association of Galpha13 and the Dbl homology domain. PMID: 22661716
  21. signaling-selective inhibition of the CXCR4-Galpha(13)-Rho axis prevents the metastatic spread of basal-like breast cancer cells. PMID: 21934106
  22. alpha subunit of the G protein G13 regulates activity of one or more Gli transcription factors independently of smoothened PMID: 21757753
  23. Negative regulation of Gq-mediated pathways in platelets by G(12/13) pathways through Fyn kinase PMID: 21592972
  24. Galpha(12/13) regulate AP-1-dependent CYR61 induction in vascular smooth muscle, promoting migration, and they are upregulated with CYR61 in arteriosclerotic lesions. PMID: 21212405
  25. A new role is described for Galpha13 as a mediator of chemokine receptor CXCR4 endosomal trafficking in human T cells. PMID: 21148034
  26. Galpha(12) binds to p120(ctn) and modulates its phosphorylation status through a Rho-independent mechanism. Galpha(12) emerges as an important regulator of p120(ctn) function PMID: 20974127
  27. Galpha12/13 upregulate matrix metalloproteinase-2 via p53 promoting human breast cell invasion. PMID: 20044778
  28. G(alpha)(12) and G(alpha)13) exert a complex pattern of nonredundant effects in small cell lung cancer cells PMID: 20160064
  29. This review gives an overview of Galpha12/13 signaling of G protein-coupled receptors with a focus on RhoGTPase nucleotide exchange factor (RhoGEF) proteins as the immediate mediators of G12/13 activation. PMID: 19226283
  30. The studies highlighted in this review provide compelling evidence that Galpha12 and Galpha13 play pivotal roles in many aspects of cancer invasion and metastasis. PMID: 19422395
  31. study demonstrates not only a function of integrin alphaIIbbeta3 as a noncanonical Galpha13-coupled receptor but also a new concept of Galpha13-dependent dynamic regulation of RhoA PMID: 20075254
  32. Galpha12 and Galpha13 negatively regulate the adhesive functions of cadherin PMID: 11976333
  33. Galpha13 is not associated with lipid rafts PMID: 12117999
  34. Galpha13 can induce ppET-1 gene expression through a JNK-mediated pathway. PMID: 12135322
  35. co-stimulation of G(12/13) and G(i) pathways is sufficient to activate GPIIb/IIIa in human platelets in a mechanism that involves intracellular calcium PMID: 12297512
  36. These results suggest that protein kinase A blocks Rho activation by phosphorylation of Galpha(13) Thr(203). PMID: 12399457
  37. Selective activation of Galpha(12) and Galpha(13) by thrombin and LPA, respectively, is determined by the N-terminal short sequences of alpha subunits. PMID: 12594220
  38. Several features of a typical alpha/RGS interaction are preserved in the alpha(13)/p115RhoGEF interaction. PMID: 15735747
  39. Galpha13-induced VASP phosphorylation that involves activation of RhoA and MEKK1, phosphorylation and degradation of IkappaB, release of PKA catalytic subunit from the complex with IkappaB and NF-kappaB, and subsequent phosphorylation of VASP PMID: 16046415
  40. analysis of the molecular mechanism of how the human TXA2 receptor interacts with G alpha 13 to activate intracellular signaling PMID: 16212421
  41. Estrogen receptor alpha interacts with Galpha13 to drive actin remodeling and endothelial cell migration. PMID: 16601072
  42. Results identify the G12 family proteins Galpha12 and 13 as important regulators of prostate cancer invasion and suggest that these proteins may be targeted to limit invasion- and metastasis-induced prostate cancer patient mortality. PMID: 16787920
  43. Galpha13-Rho signaling axis is required for SDF-1-induced migration through CXCR4 PMID: 17056591
  44. Distinct regions of Galpha13 participate in its regulatory interactions with RGS homology domain-containing RhoGEFs. PMID: 17449226
  45. analysis of a novel cross-talk exerted from the LPA/Galpha(13)/p115RhoGEF/RhoA pathway to the beta(2)-adrenergic receptor/Galpha(s)/adenylyl cyclase pathway PMID: 17493936
  46. G alpha(12/13) regulate basal p53 levels via mdm4, which constitutes a cell signaling pathway distinct from p53 phosphorylations elicited by genotoxic stress. PMID: 17510313
  47. role in regulating ASK1 expression levels PMID: 17595347
  48. provides first examination of Galpha12 and Galpha13 in the human heart, demonstrating selective activation of human atrial Galpha12 and Galpha13 by endothelin and angiotensin receptors, respectively PMID: 17878759
  49. A pronounced and rapid translocation of p115-RhoGEF from the cytosol to the plasma membrane was observed upon activation of several G(12/13)-coupled receptors in a cell type-independent fashion. PMID: 18320579
  50. AC7 is a specific downstream effector of the G(12/13) pathway PMID: 18541530
  51. RGS22 may also play a role in GNA13 translocation from the cytoplasm to the nucleus during spermiogenesis PMID: 18703424
  52. Protein kinase C-related kinase and ROCK are required for thrombin-induced endothelial cell permeability downstream from Galpha12/13 and Galpha11/q PMID: 18713748
  53. G(alpha)(13)-dependent downstream effects on RhoA activation and invasion tightly depend on cell type-specific GAP activities and that G(alpha)(13)-p190RhoGAP signaling might represent a potential target for intervention in melanoma metastasis. PMID: 18922893
  54. LARG activation is regulated by an induced-fit mechanism through the GAP interface of Galpha(13). PMID: 19074425
  55. MEF2 proteins are an important component in Galpha13-mediated angiogenesis. PMID: 19093215
  56. Galpha(13) is haploinsufficient for adult angiogenesis in both the female reproductive system and tumor angiogenesis. PMID: 19654325
  57. TXA(2) receptor mediates water influx through aquaporins in astrocytoma cells via TXA(2) receptor-mediated activation of G alpha(12/13), Rho A, Rho kinase and Na(+)/H(+)-exchanger. PMID: 19772916

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Subcellular Location Cell membrane, Lipid-anchor, Melanosome, Cytoplasm, Nucleus
Protein Families G-alpha family, G(12) subfamily
Tissue Specificity Expressed in testis, including in Leydig cells and in the seminiferous epithelium, in differentiating cells from the spermatogonia to mature spermatozoa stages and round spermatids (at protein level). Expressed in 99.2% of spermatozoa from healthy individ
Database Links

HGNC: 4381

OMIM: 604406

KEGG: hsa:10672

STRING: 9606.ENSP00000400717

UniGene: Hs.515018

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