GPC5 Antibody

1. Our results showed that GPC5 was lowly expressed in PCa cell lines. PMID: 28893348
2. Taken together, our results suggest GPC5 as a tumor suppressor in PDAC and its expression is possibly regulated by miR-4295. Our study indicates that the miR-4295/GPC5 axis may play an important role in the pathogenesis of PADC and has potential applications for the development of PDAC therapy. PMID: 29407175
3. Suggest that GPC5 is able to suppress the lung adenocarcinoma metastasis by competitively binding to Wnt3a and inactivating the Wnt/beta-catenin signaling pathway. PMID: 27806326
4. GPC5 is a novel epigenetically silenced tumor suppressor, which inhibits tumor growth by suppressing Wnt/beta-catenin signaling in lung adenocarcinoma. PMID: 27157618
5. GPC5 protein expression showed a close correlation with the tumorigenesis and tumor progression of prostate cancer, and that might be applied as a novel biomarker for the prediction of diagnosis and prognosis of prostate cancer. PMID: 26631038
6. These results suggest that miR-297 acted as an oncogenic miRNA, partly by targeting GPC5, adenocarcinoma of the lung. PMID: 27554041
7. Results suggest a potential association between CRP and GPC5 variants with lung cancer risk; variation in GKN1 is associated with chemotherapy response in the Chinese Han population. PMID: 25999661
8. miR-709 may positively regulate invasion and metastasis of hepatocellular carcinoma through targeting GPC5. PMID: 25818666
9. gene variants in IRF5, IRF8 and GPC5 were not associated with risk of relapse or disease progression in multiple sclerosis PMID: 24943672
10. GPC5, a tumor suppressor, is regulated by miR-620 in lung adenocarcinoma. PMID: 24682381
11. Variants in the 50-upstream region of GPC5 confer risk of lung cancer in never smokers PMID: 24456789
12. These results indicate that GPC5 polymorphisms would be useful genetic indicators for Inflammatory demyelinating diseasess, including neuromyelitis optica and multiple sclerosis . PMID: 24135429
13. The IL7R, TNFRSF1A, and GPC5 polymorphisms tended to be associated with having a second event of Multiple sclerosis within a year. PMID: 24130709
14. Shh binds to HSPG co-receptors containing a glypican 5 core and 2-O-sulfo-iduronic acid to promote neural precursor proliferation. PMID: 23867465
15. Data suggest that glypican-5 (GPC5) is a metastasis suppressor gene in non-small cell lung cancer (NSCLC) and may be a potential biomarker that predicts NSCLC metastasis. PMID: 23962560
16. GPC5 is a gene required for normal neural tube development. PMID: 23223018
17. findings suggested that SNP rs2352028 in GPC5 might confer a slight risk to lung cancer/adenocarcinoma PMID: 22236185
18. GPC5 stimulates Hh signaling by facilitating/stabilizing the interaction between Hh and Ptc1. PMID: 21339334
19. GPC5 is a novel genetic locus protective against sudden cardiac arrest PMID: 20360844
20. This study supports that multiple sclerosis susceptibility at 13q31-32 may localize to the Glypican-5 gene. PMID: 20692050
21. No association between GPC5rs2352028 variant and lung cancer in never smokers in meta-analysis of 7 genome-wide association studies under the random effects model. PMID: 20688270
22. GPC5 polymorphism associated with susceptibility to lung cancer in never smokers PMID: 20304703
23. GPC5 is a possible target for the 13q31-q32 amplification detected in lymphoma cell lines. PMID: 12721791
24. Independent replication confirms GPC5 as a genetic risk factor for multiple sclerosis. PMID: 19010793
25. ZIC2, SPRY2, and GPC5 genes are candidate genes suspected to explain the malformations associated with cerebral anomalies in the hypothesis of a contiguous gene syndrome in 13q deletion syndrome PMID: 19022413
26. Confirm the association of polymorphisms within GPC5 with response to interferon-beta therapy in patients with multiple sclerosis. PMID: 19556317
27. Genome-wide association study of gene-disease association and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 18195134

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HGNC: 4453

OMIM: 602446

KEGG: hsa:2262

STRING: 9606.ENSP00000366267

UniGene: Hs.655675