GPR34 Antibody

1. By monitoring fused FLAG-tag and conformation-sensitive native epitope during expression of GPR34 mutants, a tri-basic motif in the first intracellular loop was identified as key topogenic signal that dictates the orientation of transmembrane domain-1. PMID: 27086875
2. GPR34 knockdown impairs the proliferation and migration of HGC-27 gastric cancer cells in vitro and provides a potential implication for therapy of gastric cancer. PMID: 25673461
3. up-regulation of GPR34 expression in human gastric carcinoma may play a critical role in tumor progression and in determining patient prognosis PMID: 23836308
4. The present studies confirm that GPR34 is a cellular receptor for LysoPS, especially with a fatty acid at the sn-2 position. PMID: 22343749
5. these results are the first to identify a role for a GPR34 in lymphoma cell growth, provide insight into GPR34-mediated signaling, identify a genetically unique subset of MZLs that express high levels of GPR34. PMID: 22966169
6. data show that multiple translation initiation starts and alternative splicing contribute to the supragenomic diversification of GPR34 PMID: 16338117

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HGNC: 4490

OMIM: 300241

KEGG: hsa:2857

STRING: 9606.ENSP00000367378

UniGene: Hs.495989