GPRC6A Antibody

Code CSB-PA008232
Size US$100
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  • Western Blot analysis of Jurkat cells using GPRC6A Polyclonal Antibody
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Product Details

Uniprot No.
Target Names
Alternative Names
bA86F4.3 antibody; G protein coupled receptor 33 antibody; G protein coupled receptor family C group 6 member A antibody; G-protein coupled receptor family C group 6 member A antibody; G-protein coupled receptor GPCR33 antibody; GPC6A_HUMAN antibody; GPCR 33 antibody; GPCR 6A antibody; GPCR antibody; GPCR33 antibody; GPCR6A antibody; GPR C6A antibody; GPRC 6A antibody; gprc6a antibody; hGPCR 33 antibody; hGPCR33 antibody; hGPRC6A antibody; OTTHUMP00000017075 antibody; Predicted with SOSUI analysis antibody; seven transmembrane helix receptor antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthesized peptide derived from the Internal region of Human GPRC6A.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, IF, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IF 1:200-1:1000
ELISA 1:5000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Receptor activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids. The L-alpha amino acids respond is augmented by divalent cations Ca(2+) and Mg(2+). Activated by extracellular calcium and osteocalcin. Seems to act through a G(q)/G(11) and G(i)-coupled pathway. Mediates the non-genomic effects of androgens in multiple tissue. May coordinate nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalent ions and its responsiveness to anabolic steroids.
Gene References into Functions
  1. If the regulatory functions of GPRC6A identified in mice translate to humans, and polymorphisms in GPRC6A are found to predict racial disparities in human diseases, GPRC6A may be a new gene target to predict, prevent, and treat MetS, PCa, and other disorders impacted by GPRC6A. PMID: 28180060
  2. Human GPRC6A is a functional osteocalcin and testosterone sensing receptor that promotes prostate cancer progression. PMID: 28659174
  3. he nonrare polymorphism rs2274911 in the GPRC6A gene was associated with insulin resistance features, independently of the metabolic phenotype and osteocalcin levels. PMID: 27696500
  4. Genetic Variations in the Human G Protein-coupled Receptor Class C, Group 6, Member A (GPRC6A) Control Cell Surface Expression and Function PMID: 27986810
  5. Osteocalcin and Sex Hormone Binding Globulin Compete on a Specific Binding Site of GPRC6A. PMID: 27673554
  6. results suggest that G protein-coupled receptor class C group 6 member A(GPRC6A) inactivation or sub-function contributes to reduced exposure to androgens, leading to cryptorchidism during fetal life and/or low sperm production in adulthood PMID: 26735260
  7. association of the THADA, FOXP4, GPRC6A/RFX6 and 8q24 genes with prostate cancer in Asian populations. PMID: 26537068
  8. The present experiments demonstrated a critical role for the GPRC6A-ERK1/2 and PI3K/Akt signaling pathway in arginine-mediated fibroblast survival. PMID: 24651445
  9. Duox1 activity is stimulated by testosterone through GPRC6A in skin keratinocytes PMID: 25164816
  10. The F464Y substitution in GPRC6A may be a cause of primary testicular failure. PMID: 23728177
  11. Extracellular Ca2+ activates the NLRP3 inflammasome via CaSR and GPRC6A. PMID: 23271661
  12. the GPRC6A receptor functions as an amino acid sensor in GLUTag cells that promotes GLP-1 secretion PMID: 23269670
  13. Our results provide further support for association of the C2orf43, FOXP4, GPRC6A and RFX6 genes with prostate cancer in Eastern Asian populations PMID: 22662242
  14. GPRC6A is a novel molecular target for regulating prostate growth and cancer progression. PMID: 21681779
  15. Observational study of gene-disease association. (HuGE Navigator) PMID: 20654748
  16. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 20676098
  17. that GPRC6A gene polymorphisms were significantly associated with human spine BMD. PMID: 19874200
  18. GPRC6A is widely expressed in brain and peripheral tissues with highest levels in kidney, skeletal muscle, testis, and leucocytes. PMID: 15194188
  19. elucidating agonist interaction with GPRC6A, a novel family C G-protein-coupled receptor. PMID: 15576628
  20. GPRC6A is a cation-, calcimimetic-, and osteocalcin-sensing receptor PMID: 16199532

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Subcellular Location
Cell membrane; Multi-pass membrane protein.
Protein Families
G-protein coupled receptor 3 family
Tissue Specificity
Isoform 1 is expressed at high level in brain, skeletal muscle, testis, bone, calvaria, osteoblasts and leukocytes. Expressed at intermediate level in liver, heart, kidney and spleen. Expressed at low level in lung, pancreas, placenta and ovary. Not detec
Database Links

HGNC: 18510

OMIM: 613572

KEGG: hsa:222545

STRING: 9606.ENSP00000309493

UniGene: Hs.266745

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