GPRC6A Antibody, Biotin conjugated

1. If the regulatory functions of GPRC6A identified in mice translate to humans, and polymorphisms in GPRC6A are found to predict racial disparities in human diseases, GPRC6A may be a new gene target to predict, prevent, and treat MetS, PCa, and other disorders impacted by GPRC6A. PMID: 28180060
2. Human GPRC6A is a functional osteocalcin and testosterone sensing receptor that promotes prostate cancer progression. PMID: 28659174
3. he nonrare polymorphism rs2274911 in the GPRC6A gene was associated with insulin resistance features, independently of the metabolic phenotype and osteocalcin levels. PMID: 27696500
4. Genetic Variations in the Human G Protein-coupled Receptor Class C, Group 6, Member A (GPRC6A) Control Cell Surface Expression and Function PMID: 27986810
5. Osteocalcin and Sex Hormone Binding Globulin Compete on a Specific Binding Site of GPRC6A. PMID: 27673554
6. results suggest that G protein-coupled receptor class C group 6 member A(GPRC6A) inactivation or sub-function contributes to reduced exposure to androgens, leading to cryptorchidism during fetal life and/or low sperm production in adulthood PMID: 26735260
7. association of the THADA, FOXP4, GPRC6A/RFX6 and 8q24 genes with prostate cancer in Asian populations. PMID: 26537068
8. The present experiments demonstrated a critical role for the GPRC6A-ERK1/2 and PI3K/Akt signaling pathway in arginine-mediated fibroblast survival. PMID: 24651445
9. Duox1 activity is stimulated by testosterone through GPRC6A in skin keratinocytes PMID: 25164816
10. The F464Y substitution in GPRC6A may be a cause of primary testicular failure. PMID: 23728177
11. Extracellular Ca2+ activates the NLRP3 inflammasome via CaSR and GPRC6A. PMID: 23271661
12. the GPRC6A receptor functions as an amino acid sensor in GLUTag cells that promotes GLP-1 secretion PMID: 23269670
13. Our results provide further support for association of the C2orf43, FOXP4, GPRC6A and RFX6 genes with prostate cancer in Eastern Asian populations PMID: 22662242
14. GPRC6A is a novel molecular target for regulating prostate growth and cancer progression. PMID: 21681779
15. Observational study of gene-disease association. (HuGE Navigator) PMID: 20654748
16. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 20676098
17. that GPRC6A gene polymorphisms were significantly associated with human spine BMD. PMID: 19874200
18. GPRC6A is widely expressed in brain and peripheral tissues with highest levels in kidney, skeletal muscle, testis, and leucocytes. PMID: 15194188
19. elucidating agonist interaction with GPRC6A, a novel family C G-protein-coupled receptor. PMID: 15576628
20. GPRC6A is a cation-, calcimimetic-, and osteocalcin-sensing receptor PMID: 16199532

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HGNC: 18510

OMIM: 613572

KEGG: hsa:222545

STRING: 9606.ENSP00000309493

UniGene: Hs.266745