GPSM3 Antibody

1. role for GPSM3 in neutrophil migration toward proinflammatory chemoattractants LTB4 and CXCL8-a discovery that helps strengthen the association between the promoter-weakening GPSM3 SNP rs204989 and a reduced risk of rheumatoid arthritis PMID: 27307211
2. Genetic variations in GPSM3 which are associated with protection from rheumatoid arthritis affect its transcript abundance. PMID: 26821282
3. findings suggest that GPSM3 acts as a direct negative regulator of NLRP3 function. PMID: 25271165
4. Phosphorylation of GPSM3 by a proline-directed serine/threonine kinase and the resultant association of 14-3-3 is the first description of post-translational regulation of GPSM3 subcellular localization PMID: 22843681
5. GPSM3 increases Gbeta stability until formation of the Gbetagamma dimer, including association of the Gbeta-GPSM3 complex with phosducin-like protein PhLP and T-complex protein 1 subunit eta (CCT7), two known chaperones of neosynthesized Gbeta subunits. PMID: 22167191
6. AGS4-Galpha(i) complexes directly couple to a G-protein-coupled receptor and may serve as substrates for agonist-induced G-protein activation. PMID: 20452976
7. Mutational analysis of the role of GoLoco motifs in guanine nucleotide dissociation inhibitor activity of G18 protein. PMID: 14656218

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HGNC: 13945

KEGG: hsa:63940

STRING: 9606.ENSP00000364180

UniGene: Hs.520046