GPSM3 Antibody, FITC conjugated

Code CSB-PA896517LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) GPSM3 Polyclonal antibody
Uniprot No.
Target Names
GPSM3
Alternative Names
Activator of G-protein signaling 4 antibody; AGS4 antibody; C6orf9 antibody; G protein signalling modulator 3 (AGS3 like; C. elegans) antibody; G-protein signaling modulator 3 (AGS3-like; C. elegans) antibody; G-protein-signaling modulator 3 antibody; G18 antibody; G18.1a antibody; G18.1b antibody; G18.2 antibody; Gpsm3 antibody; GPSM3_HUMAN antibody; NG1 antibody; OTTHUMP00000029351 antibody; Protein G18 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human G-protein-signaling modulator 3 protein (1-160AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Interacts with subunit of G(i) alpha proteins and regulates the activation of G(i) alpha proteins.
Gene References into Functions
  1. role for GPSM3 in neutrophil migration toward proinflammatory chemoattractants LTB4 and CXCL8-a discovery that helps strengthen the association between the promoter-weakening GPSM3 SNP rs204989 and a reduced risk of rheumatoid arthritis PMID: 27307211
  2. Genetic variations in GPSM3 which are associated with protection from rheumatoid arthritis affect its transcript abundance. PMID: 26821282
  3. findings suggest that GPSM3 acts as a direct negative regulator of NLRP3 function. PMID: 25271165
  4. Phosphorylation of GPSM3 by a proline-directed serine/threonine kinase and the resultant association of 14-3-3 is the first description of post-translational regulation of GPSM3 subcellular localization PMID: 22843681
  5. GPSM3 increases Gbeta stability until formation of the Gbetagamma dimer, including association of the Gbeta-GPSM3 complex with phosducin-like protein PhLP and T-complex protein 1 subunit eta (CCT7), two known chaperones of neosynthesized Gbeta subunits. PMID: 22167191
  6. AGS4-Galpha(i) complexes directly couple to a G-protein-coupled receptor and may serve as substrates for agonist-induced G-protein activation. PMID: 20452976
  7. Mutational analysis of the role of GoLoco motifs in guanine nucleotide dissociation inhibitor activity of G18 protein. PMID: 14656218

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Subcellular Location
Cytoplasm.
Tissue Specificity
Expressed in heart, placenta, lung and liver.
Database Links

HGNC: 13945

KEGG: hsa:63940

STRING: 9606.ENSP00000364180

UniGene: Hs.520046

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