GRHPR Antibody

Code CSB-PA009897HA01HU
Size US$166
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  • Western Blot
    Positive WB detected in: Rat liver tissue, Mouse liver tissue
    All lanes: GRHPR antibody at 3.5μg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 36, 28 kDa
    Observed band size: 36 kDa

  • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA009897HA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA009897HA01HU at dilution of 1:100

  • Immunofluorescent analysis of HepG2 cells using CSB-PA009897HA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) GRHPR Polyclonal antibody
Uniprot No.
Target Names
GRHPR
Alternative Names
GLXR antibody; glycerate 2 dehydrogenase antibody; GLYD antibody; Glyoxylate reductase/hydroxypyruvate reductase antibody; Grhpr antibody; GRHPR_HUMAN antibody; OTTHUMP00000021379 antibody; OTTHUMP00000021380 antibody; OTTHUMP00000046131 antibody; PH 2 antibody; PH2 antibody; Primary hyperoxaluria type 2 antibody
Raised in
Rabbit
Species Reactivity
Human, Mouse, Rat
Immunogen
Recombinant Human Glyoxylate reductase/hydroxypyruvate reductase protein (1-328AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The GRHPR Antibody (Product code: CSB-PA009897HA01HU) is Non-conjugated. For GRHPR Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA009897HB01HU GRHPR Antibody, HRP conjugated ELISA
FITC CSB-PA009897HC01HU GRHPR Antibody, FITC conjugated
Biotin CSB-PA009897HD01HU GRHPR Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC, IF
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
IHC 1:20-1:200
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate oxidizes D-glycerate to hydroxypyruvate.
Gene References into Functions
  1. GRHPR was genotyped in Japanese patients with PH2 and all GRHPR mutations described to date were reviewed in terms of geographic and ethnic association PMID: 24116921
  2. Our findings suggest that the GRHPR defect in noncancerous tissues may represent an independent predictor of poor survival for hepatocellular carcinoma patients after curative resection PMID: 23486161
  3. GRHPR directly interacts with SVCT1. PMID: 23599041
  4. substrate specificity of human glyoxylate reductase PMID: 16756993
  5. the GRHPR gene may have a role in primary hyperoxaluria type 2 in a Japanese patient [case report] PMID: 17510093

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Involvement in disease
Hyperoxaluria primary 2 (HP2)
Protein Families
D-isomer specific 2-hydroxyacid dehydrogenase family
Tissue Specificity
Ubiquitous. Most abundantly expressed in the liver.
Database Links

HGNC: 4570

OMIM: 260000

KEGG: hsa:9380

STRING: 9606.ENSP00000313432

UniGene: Hs.155742

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