GRIN2C Antibody

Code CSB-PA583461
Size US$299 How to order?
Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA583461(GRIN2C Antibody) at dilution 1/80, on the right is treated with synthetic peptide. (Original magnification: ×200)
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Product Details

Uniprot No. Q14957
Target Names GRIN2C
Alternative Names GluN2C antibody; Glutamate [NMDA] receptor subunit epsilon-3 antibody; Glutamate Receptor Ionotropic N Methyl D Aspartate 2C antibody; Glutamate receptor ionotropic, NMDA 2C antibody; Glutamate receptor, ionotropic, N methyl D aspartate 2C antibody; Grin2c antibody; N Methly D Aspartate Receptor Channel Subunit Epsilon 3 antibody; N Methyl D Aspartate Receptor Subtype 2C antibody; N methyl D aspartate receptor subunit 2C antibody; N-methyl D-aspartate receptor subtype 2C antibody; NMDAR2C antibody; NMDE3_HUMAN antibody; NR2C antibody; OTTHUMP00000041930 antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Synthetic peptide of Human GRIN2C
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Isotype IgG
Purification Method Antigen affinity purification
Concentration It differs from different batches. Please contact us to confirm it.
Buffer -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form Liquid
Tested Applications ELISA,IHC
Recommended Dilution
Application Recommended Dilution
ELISA 1:2000-1:10000
IHC 1:100-1:300
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition (Probable). Plays a role in regulating the balance between excitatory and inhibitory activity of pyramidal neurons in the prefrontal cortex. Contributes to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning.
Gene References into Functions
  1. ultra-rare variants with loss of function (frameshift, nonsense or splice site) in NMDARs genes like GRIN2C and GRIN2D may contribute to possible risk of schizophrenia PMID: 29317596
  2. Findings indicate that SNPs in the GRIN2C gene is associated with altered cue-induced brain activation that is related to craving for alcohol and relapse risk. PMID: 26289945
  3. these findings highlight the isoform-specific structural and functional differences within the 14-3-3 family of proteins, which determine GluN2C binding and its essential role in targeting the receptor to the cell surface PMID: 26229101
  4. The major depression subjects exhibited significantly higher expression levels of the NMDA receptor subunit genes GRIN2C. PMID: 24925192
  5. TNFalpha significantly upregulates NMDA-R2C mRNA expression, in differentiated, confluent, normal keratinocytes but not in involved or uninvolved psoriatic keratinocyte monolayers PMID: 24102971
  6. The authors identified and cloned sequences of NMDA receptor subunits 2A, 2B, and 2C from rat. They characterized the properties of the receptors composed of heteromeric 1-2A and heteromeric 1-2C and found that the latter had reduced sensitivity to magnesium and smaller conductance compared to the former. PMID: 1350383
  7. Functional compensation could occur to counteract the loss of one allele in GRIN2C and GRIN3 family genes. PMID: 22833210

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Subcellular Location Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
Protein Families Glutamate-gated ion channel (TC 1.A.10.1) family, NR2C/GRIN2C subfamily
Tissue Specificity Mainly expressed in brain with predominant expression is in the cerebellum, also present in the hippocampus, amygdala, caudate nucleus, corpus callosum, subthalamic nuclei and thalamus. Detected in the heart, skeletal muscle and pancreas.
Database Links

HGNC: 4587

OMIM: 138254

KEGG: hsa:2905

STRING: 9606.ENSP00000293190

UniGene: Hs.436980

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