GRIN2C Antibody, HRP conjugated

1. ultra-rare variants with loss of function (frameshift, nonsense or splice site) in NMDARs genes like GRIN2C and GRIN2D may contribute to possible risk of schizophrenia PMID: 29317596
2. Findings indicate that SNPs in the GRIN2C gene is associated with altered cue-induced brain activation that is related to craving for alcohol and relapse risk. PMID: 26289945
3. these findings highlight the isoform-specific structural and functional differences within the 14-3-3 family of proteins, which determine GluN2C binding and its essential role in targeting the receptor to the cell surface PMID: 26229101
4. The major depression subjects exhibited significantly higher expression levels of the NMDA receptor subunit genes GRIN2C. PMID: 24925192
5. TNFalpha significantly upregulates NMDA-R2C mRNA expression, in differentiated, confluent, normal keratinocytes but not in involved or uninvolved psoriatic keratinocyte monolayers PMID: 24102971
6. The authors identified and cloned sequences of NMDA receptor subunits 2A, 2B, and 2C from rat. They characterized the properties of the receptors composed of heteromeric 1-2A and heteromeric 1-2C and found that the latter had reduced sensitivity to magnesium and smaller conductance compared to the former. PMID: 1350383
7. Functional compensation could occur to counteract the loss of one allele in GRIN2C and GRIN3 family genes. PMID: 22833210

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HGNC: 4587

OMIM: 138254

KEGG: hsa:2905

STRING: 9606.ENSP00000293190

UniGene: Hs.436980