GSPT2 Antibody

Code CSB-PA009967GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
GSPT2
Alternative Names
eRF3b antibody; ERF3B_HUMAN antibody; Eukaryotic peptide chain release factor GTP-binding subunit ERF3B antibody; Eukaryotic peptide chain release factor subunit 3b antibody; G1 to S phase transition 2 antibody; G1 to S phase transition protein 2 homolog antibody; Gspt2 antibody; GST2 antibody; peptide chain release factor 3 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human GSPT2
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IHC
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Involved in translation termination in response to the termination codons UAA, UAG and UGA. May play a role as a potent stimulator of the release factor activity of ETF1. Exhibits GTPase activity, which is ribosome- and ETF1-dependent. May play a role in cell cycle progression. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.
Gene References into Functions
  1. Loss of GSPT2 and/or MAGED1 function may contribute to the intellectual disability. PMID: 28414775
  2. The survivin and eRF3 complex may function in spindle formation and segregation of chromosomes and cytokinesis. PMID: 23377885
  3. The tumor marker eRF3B can change the cell cycle and influence the phosphorylation status of 4E-BP1. PMID: 24466059
  4. The proteolytic cleavage of eRF3a and eRF3b into p-eRF3 leads to release an amino-terminal fragment containing nuclear export signal to allow the relocalization of eRF3 into the nucleus to interact with the p14ARF. PMID: 24569073
  5. eRF3b can substitute for eRF3a in its translation termination function. PMID: 15987998
  6. eRF1's M domain contacts eRF3's GTPase domain PMID: 19417105

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Subcellular Location
Cytoplasm.
Protein Families
TRAFAC class translation factor GTPase superfamily, Classic translation factor GTPase family, ERF3 subfamily
Tissue Specificity
Highly expressed in IUCC stage II colorectal cancer (CRC).
Database Links

HGNC: 4622

OMIM: 300418

KEGG: hsa:23708

STRING: 9606.ENSP00000341247

UniGene: Hs.59523

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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