GTF2H2 Antibody

1. interface variants between the p34 and p44 subunits only mildly affected the association between the full length proteins and did not impinge on TFIIH activities due to the presence of an additional interface involving the C4 domain of p34. PMID: 28977422
2. Advanced oxidation protein products down-regulate the expression of calcium transport channels through p44/42 MAPK signaling mechanisms in the small intestinal epithelium. PMID: 25801217
3. Together, these results suggest that p44/WDR77 expression causes the non-sensitivity of proliferating cells to TGFbeta signaling, thereby contributing to cellular proliferation during lung tumorigenesis. PMID: 24944016
4. No correlation was found for p44 and occludin gene copy number and spinal muscular atrophy PMID: 21821450
5. miR-27a was identified as a key regulator of p44 mRNA. Moreover, miR-27a was shown to destabilize the p44 subunit of the TFIIH complex during the G2-M phase, thereby modulating the transcriptional shutdown observed during this transition. PMID: 21558443
6. p52 Mediates XPB function within the transcription/repair factor PMID: 12080057
7. p44 of TFIIH has a role in binding to the nonstructural protein of Rift Valley fever virus to form nuclear filamentous structures PMID: 14980221
8. solution structure of p44-(321-395) shows topology differs from other reported RING domains by a circular permutation of the extended secondary structure elements; mutagenesis suggests tight binding to p34 is mediated by hydrophobic interactions PMID: 15790571
9. Impaired transcription in IPF is associated with decreased concentrations of transcription factor II-H in alveolar macrophages and may alter the intraalveolar milieu in IPF. PMID: 17332483

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HGNC: 4656

OMIM: 601748

KEGG: hsa:2966

STRING: 9606.ENSP00000274400

UniGene: Hs.191356