Guca2b Antibody

Code CSB-PA010048LA01MO
Size US$166
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Product Details

Full Product Name
Rabbit anti-Mus musculus (Mouse) Guca2b Polyclonal antibody
Uniprot No.
Target Names
Guca2b
Alternative Names
Guca2b antibody; Guanylate cyclase activator 2B [Cleaved into: Uroguanylin antibody; UGN)] antibody
Raised in
Rabbit
Species Reactivity
Mouse
Immunogen
Recombinant Mouse Guanylate cyclase activator 2B protein (22-106AA)
Immunogen Species
Mus musculus (Mouse)
Conjugate
Non-conjugated

The Guca2b Antibody (Product code: CSB-PA010048LA01MO) is Non-conjugated. For Guca2b Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA010048LB01MO Guca2b Antibody, HRP conjugated ELISA
FITC CSB-PA010048LC01MO Guca2b Antibody, FITC conjugated
Biotin CSB-PA010048LD01MO Guca2b Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport.
Gene References into Functions
  1. In obese mice UGN expression was decreased, whereas leptin treatment up-regulated UGN levels in duodenum in these genetically modified mice compared to WT. PMID: 25743370
  2. UGN exerts its inhibitory activity on the prendrin gene promoter likely via heat shock factor 1 action at a defined heat shock element site. PMID: 22129966
  3. findings establish a role for uroguanylin in an enteric-renal communication axis as well as a fundamental principle of this axis in the maintenance of salt homeostasis in vivo PMID: 14561709
  4. act on the mouse kidney, in part, through a cGMP-dependent, GC-C-independent mechanism, causing significant natriuresis by renal tubular processes. PMID: 14675035
  5. Role for uroguanylin in fluid homeostasis and as an integral component of a signaling mechanism that mediates changes in Na excretion in response to an enteral salt loading. PMID: 16819406

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Subcellular Location
Secreted.
Protein Families
Guanylin family
Tissue Specificity
Localized predominantly in intestinal villi and the corticomedullary junction of the kidney.
Database Links

KEGG: mmu:14916

STRING: 10090.ENSMUSP00000043203

UniGene: Mm.278

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