H2AFZ Antibody

Datasheet
Code CSB-PA009105
Size US$167
Uniprot No. P0C0S5
Protocols Immunohistochemistry (IHC) Protocol
ELISA Protocol
Immunogen Synthesized peptide derived from Human Histone H2A around the non-acetylation site of K5.
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Tested Applications IHC,ELISA;IHC:1/100-1/300.ELISA:1/5000
Form Liquid
Conjugate Non-conjugated
Storage Buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Alias H2AFZ; H2AZ; Histone H2A.Z; H2A/z
Immunogen Species Homo sapiens (Human)
Target Names H2AFZ
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division.
Subcellular Location Nucleus, Chromosome
Protein Families Histone H2A family
Database Links

HGNC: 4741

OMIM: 142763

KEGG: hsa:3015

STRING: 9606.ENSP00000296417

UniGene: Hs.119192

Pathway Necroptosis

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