HES5 Antibody

1. HES5 might contribute to the proliferation of non-small cell lung cancer by STAT3 signaling. PMID: 27878283
2. that suppression of the HES5 leading to inhibition of proliferation may be one of the mechanisms against Hepatocellular carcinoma PMID: 26342546
3. HES5 silencing is an early and recurrent change in prostate tumourigenesis PMID: 25560400
4. these data identify HES5 as a key mediator of the Wnt-3a proneurogenic effect occurring independently of the classical Wnt/beta-catenin signaling cascade thus further deciphering crosstalk mechanisms of Wnt and Notch signaling pathways regulating cell fate PMID: 24548083
5. the downstream Notch signalling effector HES5 directly represses transcription of the E3 ligase Fbw7beta. PMID: 23776410
6. Notch3 and Hes5 are hypermethylated in human B cell acute lymphoblastic leukemia (ALL). PMID: 23637910
7. Hes5 overactivation is associated with cell differentiation, thereby resulting in uterine carcinogenesis. PMID: 21495212
8. In this study, HES 5 transcription factor was detected in the lining epithelium of human periapical cysts with limited inflammation, showing Notch pathway activation in those cells. PMID: 21238798
9. The expression of HES5 in adenocarcinoma was significantly higher than those in adenoma and normal control PMID: 20091184
10. For marking and purifying neural stem cells to ascertain whether differences exist, we generated transgenic mice using promoters from Hes genes (pHes1 or pHes5) to drive expression of destabilized enhanced green fluorescent protein. PMID: 16214363
11. Notch protein binding to Hes5-GFP is extinguished fast and recovered slowly, whereas Hes1-GFP is inhibited late and recovered quickly PMID: 16365048
12. The HLH gene HES5 on the other hand was only detected in chondrocytes. PMID: 17072841
13. Human HES5 gene is coupled to the Notch receptor family and expression of Notch markers (including HES5) decreases during cartilage differentiation. PMID: 17093926
14. expression significantly higher in squamous cervical carcinoma than in CIN as well as higher in CIN than normal cervical epithelia PMID: 17388915
15. Data show that HES5 are abundantly expressed in osteoarthritis. PMID: 18354251
16. regulates brain development process.[review] PMID: 18524252

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HGNC: 19764

OMIM: 607348

KEGG: hsa:388585

STRING: 9606.ENSP00000367714

UniGene: Hs.57971