HEY2 Antibody

1. The findings identify HEY2 as a novel component of the NKX2-5 cardiac transcriptional network. PMID: 29636455
2. HEY2 as a promising biomarker for unfavorable outcomes and a novel therapeutic target for the clinical management of HCC PMID: 27191260
3. Genetic variation of HEY2 is associated with Brugada syndrome through alteration of ion channel expression in the cardiac ventricular wall. PMID: 28637782
4. Individuals with HEY2 duplications should be screened for congenital heart defects. PMID: 25832314
5. HEY2 CC genotype may be a favorable prognostic marker for BrS, protectively acting to prevent ventricular fibrillation presumably by regulating the repolarization current. PMID: 26729854
6. Data indicate that culture abrogated differential gene expression in part due to gradual loss of canonical Notch activity and HEY2 expression. PMID: 24108462
7. Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death PMID: 23872634
8. Hey2 and COUP-TFII have an important role in arteriovenous differentiation of human endothelial cells. PMID: 23744056
9. Report down-regulation of Notch signaling components NOTCH3 and HEY2 in abdominal aortic aneurysms. PMID: 22310065
10. Through activating the Dll4-Notch-Hey2 signaling pathway, HGF indirectly promotes the proliferation and migration ability of cells, so that offspring artery branches are formed. PMID: 21362320
11. To clarify the role of HEY2 in human CHD and AGS, we screened by direct sequencing 23 children with CHD and 38 patients diagnosed with AGS. Mutation of HEY2 is not a major contributing factor. PMID: 15389319
12. HERP1 may play a role in promoting the phenotypic modulation of vascular smooth muscle cells during vascular injury and atherosclerotic process by interfering with SRF binding to CArG-box PMID: 16151017
13. CHF1/Hey2 may affect smooth-muscle cell phenotype through an important transcriptional mechanism PMID: 16293227
14. This result suggests a possible role of HEY2 in the regulation of ventricular septation in humans. PMID: 16329098
15. The absence of mutations in NOTCH2 and Hey2 its downstream target in the heart does not exclude the possibility that other genes in this pathway might be implicated in the diverse phenotypes observed in Alagille syndrome PMID: 18266235

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HGNC: 4881

OMIM: 604674

KEGG: hsa:23493

STRING: 9606.ENSP00000357348

UniGene: Hs.144287