HIST2H2AC Antibody

1. we found an excess of mutations in genes encoding histone H2A and H2B, as well as significant amplification of the segment of chromosome 6p harboring the histone gene cluster containing these genes.We also found frequent deletions of the genes TP53 and MBD3 (a member with CHD4 of the nucleosome remodeling deacetylase complex). PMID: 27791010
2. Glycated-H2A histone is better bound by serum anti-DNA autoantibodies in systemic lupus erythematosus patients, and could be a likely trigger for the disease. PMID: 25065453
3. Our results provide mechanistic insight into how post-translational modification of H2A at the site of a photolesion initiates the repair process and directly affects the stability of the human genome. PMID: 22334663
4. Aurora-B-dependent phosphorylation of condensin promotes its association with histone H2A and H2A.Z, which we identify as conserved chromatin 'receptors' of condensin PMID: 21633354
5. L3MBTL2-specific RNAi resulted in increased expression of target genes that exhibited a significant reduction in H2A lysine 119 monoubiquitination. PMID: 21596310
6. AT1R modify the composition of histone H2A and post-translational modifications. PMID: 20838438
7. deiminated residues were present in H2A (1-56) and H4 (1-52) PMID: 15823041
8. Monoubiquitinated histone H2A in native chromatin coimmunoprecipitates with the endogenous DDB1-CUL4A(DDB2) complex in response to UV irradiation. PMID: 16473935
9. The 2 MDa GCN5 HAT-containing metazoan TFTC/STAGA complexes contain a histone H2A and H2B deubiquitinase activity. PMID: 18206972
10. DDB1-CUL4B(DDB2) is more efficient than DDB1-CUL4A(DDB2) in monoubiquitinating histone H2A in vitro. PMID: 18593899
11. The change in nucleosome core particle conformation induced by global histone acetylation is dependent on H2A/H2A.Z acetylation. PMID: 19385636
12. Study demonstrated that RNF168 is endowed with ubiquitin ligase activity both in vitro and in vivo, which targets histones H2A and H2AX, but not H2B, forming K63 polyubiquitin chains. PMID: 19500350
13. Results demonstrate the potential of C-terminal truncated H2A to contribute to the process of carcinogenesis through epigenetic mechanisms. PMID: 19667409

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HGNC: 4738

OMIM: 602797

KEGG: hsa:8338

STRING: 9606.ENSP00000332194

UniGene: Hs.408067