HOMER2 Antibody

Datasheet

Code	CSB-PA885720LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA885720LA01HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) HOMER2 Polyclonal antibody

Uniprot No.

Q9NSB8

Target Names

HOMER2

Alternative Names

HOMER2 antibody; Homer protein homolog 2 antibody; Homer-2 antibody; Cupidin antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Homer protein homolog 2 protein (1-343AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The HOMER2 Antibody (Product code: CSB-PA885720LA01HU) is Non-conjugated. For HOMER2 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA885720LB01HU	HOMER2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA885720LC01HU	HOMER2 Antibody, FITC conjugated
Biotin	CSB-PA885720LD01HU	HOMER2 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses. Required for normal hearing. Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA.

Gene References into Functions

that HOMER2 may be involved in tumourigenesis of endometrioid uterine tumours PMID: 29891190
Homer1 and Homer2 might be considered as novel diagnostic biomarkers for large-artery atherosclerosis stroke. PMID: 27832625
This study showed that HOMER2 (rs1256429; intronic, p = 8.7 x 10(1)) associated with Alzheimer disease. PMID: 25649652
These data provide compelling evidence that HOMER2 is required for normal hearing and that its sequence alteration in humans leads to ADNSHL through a dominant-negative mode of action PMID: 25816005
monitored Homer1 and Homer2 expression and subcellular localization in skeletal muscle biopsies following 60 days of bedrest PMID: 21885651
Haplotypes of the HOMER 1 and 2 genes are unlikely to play a major role in the pathophysiology of alcohol dependence. PMID: 20333726
This study supports a role for HOMER2 gene in schizophrenia susceptibility. PMID: 19914345
Polymorphism in the Homer2 gene is not a potential risk factor for the development of cocaine dependence in an African American population. PMID: 16314758

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Involvement in disease

Deafness, autosomal dominant, 68 (DFNA68)

Subcellular Location

Cytoplasm. Cell membrane. Cell junction, synapse, postsynaptic density. Cell junction, synapse. Cell projection, stereocilium. Note=Postsynaptic density of neuronal cells. The stabilization and clustering of the metabotropic glutamate receptors appears to be mediated by isoform 1 and isoform 2 at the cell surface.

Protein Families

Homer family

Database Links

HGNC: 17513

OMIM: 604799

KEGG: hsa:9455

STRING: 9606.ENSP00000305632

UniGene: Hs.578443

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Service

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Protein Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

FoxO signaling pathway Glutamatergic synapse

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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