HOMER2 Antibody, Biotin conjugated

Code CSB-PA885720LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) HOMER2 Polyclonal antibody
Uniprot No.
Target Names
HOMER2
Alternative Names
HOMER2 antibody; Homer protein homolog 2 antibody; Homer-2 antibody; Cupidin antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Homer protein homolog 2 protein (1-343AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses. Required for normal hearing. Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA.
Gene References into Functions
  1. that HOMER2 may be involved in tumourigenesis of endometrioid uterine tumours PMID: 29891190
  2. Homer1 and Homer2 might be considered as novel diagnostic biomarkers for large-artery atherosclerosis stroke. PMID: 27832625
  3. This study showed that HOMER2 (rs1256429; intronic, p = 8.7 x 10(1)) associated with Alzheimer disease. PMID: 25649652
  4. These data provide compelling evidence that HOMER2 is required for normal hearing and that its sequence alteration in humans leads to ADNSHL through a dominant-negative mode of action PMID: 25816005
  5. monitored Homer1 and Homer2 expression and subcellular localization in skeletal muscle biopsies following 60 days of bedrest PMID: 21885651
  6. Haplotypes of the HOMER 1 and 2 genes are unlikely to play a major role in the pathophysiology of alcohol dependence. PMID: 20333726
  7. This study supports a role for HOMER2 gene in schizophrenia susceptibility. PMID: 19914345
  8. Polymorphism in the Homer2 gene is not a potential risk factor for the development of cocaine dependence in an African American population. PMID: 16314758

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Involvement in disease
Deafness, autosomal dominant, 68 (DFNA68)
Subcellular Location
Cytoplasm. Cell membrane. Cell junction, synapse, postsynaptic density. Cell junction, synapse. Cell projection, stereocilium. Note=Postsynaptic density of neuronal cells. The stabilization and clustering of the metabotropic glutamate receptors appears to be mediated by isoform 1 and isoform 2 at the cell surface.
Protein Families
Homer family
Database Links

HGNC: 17513

OMIM: 604799

KEGG: hsa:9455

STRING: 9606.ENSP00000305632

UniGene: Hs.578443

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