HPD Antibody

Datasheet

Code	CSB-PA010698GA01HU
Size	$600
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

P32754

Target Names

HPD

Alternative Names

4 HPPD antibody; 4 hydroxyphenylpyruvate dioxygenase antibody; 4 hydroxyphenylpyruvic acid oxidase antibody; 4-hydroxyphenylpyruvate dioxygenase antibody; 4-hydroxyphenylpyruvic acid oxidase antibody; 4HPPD antibody; GLOD3 antibody; glyoxalase domain containing 3 antibody; HPD antibody; HPPD_HUMAN antibody; HPPDase antibody; PPD antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Human HPD

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB,IHC

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Key enzyme in the degradation of tyrosine.

Gene References into Functions

The mutagenesis and structural simulation studies demonstrate the critical and unique role of each ligand in the function of HPPD, and which correlates with their respective co-ordination position. PMID: 26936969
4-hydroxyphenylpyruvate dioxygenase gene mutation is associated with Hawkinsinuria. PMID: 26226126
Glutamine375 has a critical role for 4-HPPD in orientating the tail and ensuring the conformation of the terminal alpha-helix of the enzyme to maintain the integrity of the active site for biocatalysis. PMID: 23950902
The IIe335Met allele is equivalent to a null mutation while the Asn241Ser allele results in a partially active enzyme with an uncoupled turnover causing elevated haykinin in urine. PMID: 17560158

Involvement in disease

Tyrosinemia 3 (TYRSN3); Hawkinsinuria (HAWK)

Protein Families

4HPPD family

Database Links

HGNC: 5147

OMIM: 140350

KEGG: hsa:3242

STRING: 9606.ENSP00000289004

UniGene: Hs.2899

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Email: [email protected]
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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

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Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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