HSD17B12 Antibody, FITC conjugated

1. The expression of HSD17B12 increased along with the severity of ovarian cancer, and the expression mimicked COX-2 expression and intensity. This further suggests the involvement of HSD17B12 in AA production, and its coexpression with COX-2 indicates a role for the enzyme in the increased prostaglandin production during ovarian cancer progression. PMID: 29324448
2. Significant associations have been found between CpG sites and patient sex, including DNA methylation in CASP6, a gene that may respond to estradiol treatment, and in HSD17B12, which encodes a sex steroid hormone. PMID: 24058506
3. These evidences were suggestive of a 46,XY DSD due to 17betaHSD3 deficiency. An homozygous mutation (IVS3 -1 G>C or c.326-1G>C) of the 17betaHSD3 gene was discovered. PMID: 23435447
4. HSD17B12 overexpression is shown to be a marker of poor survival in patients with ovarian cancer; expression in the tumor and function of this enzyme facilitates ovarian cancer progression. PMID: 22903146
5. High HSD17B12 expression is associated with neoplasms. PMID: 21409596
6. 17beta-HSD12 is the major estrogenic 17beta-HSD responsible for the conversion of E1 to E2 in women. PMID: 16166196
7. Location of 17beta-hydroxysteroid dehydrogenase type 12 through the human body. PMID: 16621523
8. 17beta-HSD12 is not \related to intratumoral estradiol biosynthesis in human breast carcinoma, but is correlated with production of very long chain fatty acids and tumor progresssion. PMID: 19190350
9. determined the activity and expression levels of known estrogenic 17beta-HSDs, namely types 1, 7 and 12 17beta-HSD in preadipocytes before and after differentiation into mature adipocytes PMID: 19429442
10. There is no difference in catalytic properties between variants of 17beta-HSD types 7 and 12 and wild-type enzymes, while variants p.Glu77Gly and p.Lys183Arg in 17beta-HSD type 5 showed a slightly decreased activity. PMID: 19460435
11. SREBP-1 represents one of the transcriptional regulators of human 17beta-HSD12. PMID: 19533843

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HGNC: 18646

OMIM: 609574

KEGG: hsa:51144

STRING: 9606.ENSP00000278353

UniGene: Hs.132513