HSP90B1 Antibody

Code CSB-PA010814GA01HU
Size US$685
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Product Details

Uniprot No. P14625
Target Names HSP90B1
Alternative Names 94 kDa glucose regulated protein antibody; 94 kDa glucose-regulated protein antibody; ECGP antibody; Endoplasmin antibody; Endothelial cell (HBMEC) glycoprotein antibody; ENPL_HUMAN antibody; Glucose regulated protein 94kDa antibody; gp96 antibody; gp96 homolog antibody; GRP 94 antibody; GRP-94 antibody; Heat shock protein 90 kDa beta member 1 antibody; heat shock protein 90kDa beta (Grp94); member 1 antibody; Heat shock protein; 90 kDa; beta; 1 antibody; HSP90B1 antibody; Stress inducible tumor rejection antigen GP96 antibody; TRA1 antibody; tumor rejection antigen (gp96) 1 antibody; Tumor rejection antigen 1 antibody; Tumor rejection antigen gp96 antibody; Tumor rejection antigen-1 (gp96) antibody
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Immunogen Human HSP90B1
Immunogen Species Homo sapiens (Human)
Isotype IgG
Purification Method Antigen Affinity Purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications ELISA,WB,IHC
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity.
Gene References into Functions
  1. Glucose-regulated protein GRP94 contributes to the development of an aggressive phenotype in breast cancer cells. PMID: 29852388
  2. Concomitant high expression of ERalpha36, GRP78 and GRP94 is associated with aggressive papillary thyroid cancer behavior and may be used as a predictor for extrathyroid extension, lymph node metastasis, and distant metastasis. PMID: 29368272
  3. Overexpressed miR-150 attenuates hypoxia-induced human cardiomyocyte cell apoptosis by targeting GRP94. PMID: 29328381
  4. Regulation of CLC-1 chloride channel biosynthesis by FKBP8 and Hsp90beta as a molecular model for myotonia congenita has been described. PMID: 27580824
  5. Study demonstrated that the lack of gp96 in both the human monocytic cell line MM6 and in macrophages from LysMcre-gp96 floxed mice neither leads to a complete loss of TLR 2 expression nor to a complete loss of TLR-induced signaling, but is associated with an impaired phosphorylation of ERK and p38. These results reveal for the first time a crucial role for gp96 in the regulation of ERK and p38 kinases. PMID: 29447283
  6. HSP-gp96 promotes T cell response, enhances DC antigen presentation and induces cytokine secretion in human gastric cancer cell lines. PMID: 28706421
  7. our results besides adding further evidence in support of Grp94 as the shared tumor antigen in tumors of the GI tract, prove that it can be measured in plasma as valuable diagnostic marker of disease in the form of complexes with IgG that also exert immune-modulating activities on circulating immune cells. PMID: 27662661
  8. High GRP94 expression is associated with endometrioid adenocarcinoma. PMID: 26910913
  9. Immuno-stimulating peptide derived from HMGB1 is more effective than the N-terminal domain of Gp96 as an endogenous adjuvant for improvement of protein vaccines. PMID: 28000571
  10. These data demonstrate the essential role of the gp96-TLR interaction in priming T cell immunity and provide further molecular basis for the coupling of gp96-mediated innate with adaptive immunity. PMID: 27183126
  11. mutations in GRP94 that affect its IGF chaperone activity represent a novel causal genetic mechanism that limits IGF biosynthesis, quite a distinct mechanism from the known genes in the GH/IGF signaling network. PMID: 26982636
  12. In this instance, the ATP5B/CALR/HSP90B1/HSPB1/HSPD1-signaling network was revealed as the predominant target which was associated with the majority of the observed protein-protein interactions. As a result, the identified targets may be useful in explaining the anticancer mechanisms of ursolic acid and as potential targets for colorectal cancer therapy. PMID: 28347227
  13. High HSP90B1 expression is associated with non-small-cell lung cancer. PMID: 27599983
  14. data suggest that the GRP94/CCT8/c-Jun/EMT signaling cascade might be a new therapeutic target for HCC PMID: 26718209
  15. We filtered four OSCC genes including SERPINB9, SERPINE2, GAK, and HSP90B1 through the gene global prioritization score (P < 0.005). PMID: 26318431
  16. Our results demonstrated that GRP94 is a key molecule in Hepatocellular carcinoma (HCC) progression that modulates the AKT pathway and eNOS levels PMID: 26493996
  17. Results indicate that FN14 and GRP94 are prediction/prognosis markers which open up new possibilities for preventing/treating brain metastasis in breast cancer patients. PMID: 26497551
  18. This study clarifies a Grp94-mediated ERAD pathway for GABAA receptors, which provides a novel way to finely tune their function in physiological and pathophysiological conditions. PMID: 26945068
  19. GRP94 knockdown cells are defective in intracellular transport and, consequently, negatively impact the trafficking of F-actin toward the cellular cortex, integrin alpha2 and integrin alphaL toward the cell membrane and filopodia PMID: 26872972
  20. Our results indicate that GRP94 and TRAP1 might contribute more to the carcinogenesis or biology of SCLC than HSP90alpha and HSP90beta PMID: 26464709
  21. These results demonstrated the pivotal role of HSP90B1 in the proliferation and survival of ovarian cells, suggesting a critical role for HSP90B1 in the pathogenesis of PCOS. PMID: 27046189
  22. data suggest a role of infection-induced Gp96 shedding in the protection of the chlamydial replicative niche PMID: 26235316
  23. Hsp90-beta protein was over-expressed in lung adenocarcinoma tissues and was associated with poor outcomes in early stage tumors and low pathological grade tumors. PMID: 26339394
  24. Data identified critical players in the pathogenesis of chronic lymphocytic leukemia (CLL) and shows that HSP90B1 expression is modulated by miR-223 in CLL tumor and cell lines and suggest that HSP90B1 overexpression as a new pathogenic mechanism of CLL. PMID: 25880332
  25. our findings establish GRP94 as progression markers and druggable targets in glioblastoma, relating their oncogenic effects to activation of the Wnt/b-catenin signaling pathway PMID: 26108996
  26. Grp94 was detected in plasma of type 1 diabetic but not control subjects and found linked with its N-terminus to the IgG heavy chain. PMID: 26167512
  27. HSP gp96-positive expression is closely correlated with poor survival in gallbladder cancer. PMID: 25973087
  28. High BCLC staging scores, advanced cirrhosis and the overexpression of HSPA12A and HSP90B1 might be associated with poor survival from HCC, whereas high levels of HSPA4, HSPA5 and HSPA6 might be associated with earlier recurrence of HCC PMID: 25798051
  29. High HSP90B1 expression is associated with bone metastasis in renal cell carcinoma. PMID: 26115722
  30. The interaction of Grp94 with myocilin aggregates can be manipulated by cellular environment and genetics; this process can be exploited with Grp94 inhibitors to promote the clearance of toxic forms of myocilin. PMID: 25027323
  31. Results suggest an important role for HSP90B1 protein GP96 during human herpesvirus 6 HHV-6 infection, which possibly supports the cellular degradation of the virus. PMID: 25470779
  32. NF-kB significantly increased the gp96 expression by binding to the NF-kappaB binding site. PMID: 25803899
  33. GRP94 does not play a direct role in endoplasmic reticulum associated degradation. PMID: 24899641
  34. Induction of gp96-expression was higher in in vitro differentiated dendritic cells (i.v.DCs) than in in vitro differentiated macrophages (i.v.MACs), whereas monocytes (MOs) expressed only low gp96 levels. PMID: 24146856
  35. Glucose-regulated protein 94 is a downstream effector of ER-alpha36-mediated oestrogen signalling, and may be involved in ER-alpha36 function during gastric carcinogenesis. PMID: 23829397
  36. The frequency of mutant CC genotype for HSP90AA1 (rs4947C/T), mutant AA genotype for HSP90AB1 (rs13296A/G) and mutant CC genotype for HSP90B1 (rs2070908 C/G) was significantly higher in the patient group than in controls. PMID: 24511009
  37. role of HSP72 and gp96 in gastroenterological cancers PMID: 23266770
  38. Hsp90B1 is a direct target of miR-223 and miR- 223 may have a tumor suppressor function in osteosarcoma through the PI3K/Akt/mTOR pathway. PMID: 23208072
  39. glucose-regulated protein 94 is new potential discriminator for diffuse large B cell lymphoma. PMID: 22938940
  40. Grp94 triages mutant myocilin through endoplasmic reticulum-associated degradation. PMID: 23035116
  41. The Listeria-induced surface expression of Gp96 and the topology of its insertion on the plasma membrane, is reported. PMID: 23109341
  42. Our study revealed a remarkable biochemical event of gp96 silencing in murine but not human basophils, highlighting the need for caution in using mouse models to infer the function of basophils in human immune response. PMID: 22724016
  43. Patients with high Gp96 expression levels were significantly more resistant to radiotherapy in nasopharyngeal carcinoma. PMID: 22653265
  44. Chaperone gp96-independent inhibition of endotoxin response by chaperone-based peptide inhibitors. PMID: 22532561
  45. Inhibition of the humoral response was the main effect of Grp94 that significantly reduced the synthesis and secretion of both IgG and IgE antibodies in preipheral blood mononuclear cells from patients with allergic asthma. PMID: 22270544
  46. gp96 is critical for both TLR9 egress from the ER, and for protein conformational stability in the endosomal compartment. PMID: 22554506
  47. higher expression in recurrent breast cancer promotes cancer cell proliferation and migration PMID: 22245095
  48. These analyses identified decorin (DCN) and endoplasmin (HSP90B1) which play important roles regulating the tumour microenvironment and in pathways related to tumorigenesis. PMID: 22363530
  49. GRP94, FN14, and inhibin have roles in brain and non-brain metastases in ErbB-2+ and ErbB-2- breast neoplasms PMID: 21708117
  50. Gp96 is bound by the C. albicans Als3 invasin, which induces the uptake of this organism by brain endothelial cells. PMID: 21998592
  51. GP96 may play roles in radioresistance which attributes to tumor invasiveness in oral cancer patients receiving radiotherapy PMID: 21992474
  52. Gp96 or Grp78 contribute to aggressive cancers. PMID: 21642380
  53. Autoimmunity to endoplasmic reticulum molecular chaperone GRP94 is associated with a subset of myasthenia gravis patients who have additional autoimmune diseases. PMID: 21774995
  54. The endoplasmic reticulum stress response chaperone Gp96 is strongly expressed on the apical surface of ileal epithelial cells in Crohn disease patients, promoting adherent-invasive Escherichia coli invasion. PMID: 21637029
  55. up-regulated expression of GRP78 and GRP94 could possibly be involved in the pathogenesis of colorectal carcinomas. PMID: 21472681
  56. Downregulation of gp96 expression is associated with esophageal squamous cell carcinoma. PMID: 20839070
  57. Spermatozoa deficient in transgenic Hsp90beta1 cannot fertilize oocytes and exhibit large globular heads with abnormalities. PMID: 21208614
  58. surface translocation of gp96 has a role in systemic lupus erythematosus PMID: 20352117
  59. Overexpression of gp96 is associated with recurrences in chordomas. PMID: 20721957
  60. The positive rate of gp96 in primary lung cancer was remarkably higher than that in precancerous lesion and normal lung tissue. PMID: 20704820
  61. depleted in morphologically affected frontal cortex of Pick disease patients PMID: 20176102
  62. extracellular HSP90beta is a negative regulator for the activation of latent TGF-beta1 modulating TGF-beta signaling in the extracellular domain. PMID: 20599762
  63. The C-terminal of GP96 has potent adjuvant activity in eliciting a significant immune response when fused with Her2/neu. PMID: 20232284
  64. expression correlates with the progression of esophageal squamous cell carcinomas PMID: 20300187
  65. HSPgp96 may play acontributive role on the pathogenesis and development in human osteosarcoma. PMID: 19895174
  66. Endoplasmic reticulum chaperone gp96 is essential for infection with vesicular stomatitis virus PMID: 20351288
  67. Construction of the glycan tree is a key to identification of the necessary and sufficient elements in the structure-function activity of HSP96. PMID: 19578160
  68. These data identify for the first time the cellular chaperones associated with secretion of an ADAMTS protease and suggest a role for gp96 in modulating pro-ADAMTS9 processing. PMID: 19875450
  69. associated with HBV polymerase in human liver cell HepG2 PMID: 11958450
  70. OmpA of E. coli K1 interacts with a gp96-like molecule on HBMECs for invasion (Ecgp: 96-kDa human brain microvascular endothelial cell (HBMEC) glycoprotein) PMID: 12654781
  71. Heat shock protein 96 purified from melanoma or liver metastases of colon carcinoma cells contains immunogenic peptides that can be presented to CD8+ T cells and can activate them both in vitro and in vivo. PMID: 14500642
  72. Orientia tsutsugamushi down-regulated gp96 an endothelial cell line, HMEC-1. PMID: 15107540
  73. Expression of GRP94 suppressed A23187-induced apoptosis and stabilized calcium homeostasis. PMID: 15192333
  74. In patients with cholangiocellular carcinoma, the presence of cells expresing Grp94 is related to CD83-positive dendritic cells. PMID: 15257553
  75. The glucose-regulated protein (GRP94) is upregulated in human endothelial cells in response to hypoxia by HIF-1. PMID: 15620698
  76. HSP70 and grp94 express differently in cell plasma and nuclei. The expression intensity of HSP70 is related to the differentiation of esophageal carcinoma. PMID: 15637761
  77. Results strongly argue against a regular role for gp96 as a peptide chaperone in antigen processing. PMID: 15728573
  78. GRP94 is highly expressed in human gastric carcinoma BGC-823 cells through the whole cell cycle. PMID: 15962384
  79. Gp96 is exploited by Listeria monocytogenes as a receptor for cell invasion or signalling events that may interfere with the host immune response in the course of Listeria infection. PMID: 16015374
  80. These results suggest that CYP2E1 mediated oxidative stress downregulates the expression of GRP proteins in HepG2 cells and oxidative stress is an important mechanism in causing ER dysfunction in these cells. PMID: 16497268
  81. It was found that in vitro these proteins were capable of maturating human monocyte-derived dendritic cells (MDDC) isolated from healthy donors as well as from HBV-positive, hepatocellular carcinoma (HCC) patients. PMID: 16630554
  82. TLR4 signaling to lipopolysaccharide can be positively enforced by expressing gp96 on cell surfaces through the chaperone function of, but not the direct signaling by, transgenic gp96. PMID: 17082602
  83. ICMT inhibition induces endothelial cell apoptosis through GRP94 PMID: 17347446
  84. Retention of amyloidogenic mutant TTRs induced the unfolded protein response and upegulated the expression of GRP94. PMID: 17431395
  85. NTN4, TRA1, and STC2 have roles in progression of breast cancer PMID: 17545519
  86. These results suggest that a novel mechanism other than endoplasmic reticulum(ER) stress element-dependent mRNA transcription is required for induction of GRP94 and phosphorylation of PKR contributes to the induction of GRP94 under ER stress. PMID: 17612505
  87. Immunohistochemical analysis showed highly expressed Grp94 in primary OSCCs (oral squamous cell carcinoma). Grp94 may have potential clinical application as a novel diagnosis and prognostic biomarker for human OSCCs. PMID: 17726464
  88. HSP90B1 may have a pathophysiological role in bipolar disorder in the Japanese population. PMID: 17805476
  89. results indicate a significant correlation between the immunopositivity of HSP72 and gp96 and the progression of colonic carcinomas PMID: 18155754
  90. Heat shock protein 90beta1 is essential for polyunsaturated fatty acid-induced mitochondrial Ca2+ efflux PMID: 18178560
  91. We found higher expression of gp96 protein in breast carcinoma cells and low or no expression in normal breast cells. PMID: 18190237
  92. OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD PMID: 18264092
  93. These data indicate that HCV E2 blocks apoptosis induced by HCV infection and the host immune system through overproduction of GRP94, and that HCV E2 plays an important role in persistent HCV infection. PMID: 18273841
  94. We could demonstrate an association of GRP78 and GRP94 mRNA and protein expression with tumor stage and behaviour in esophageal adenocarcinomas. PMID: 18331622
  95. the novel involvement of GRP94 suppression in prostate cancer metastasis. PMID: 18340425
  96. We conclude that human colonocyte gp96 serves as a plasma membrane binding protein that enhances cellular entry of Clostridium difficile toxin A (TxA), participates in cellular signaling events in the inflammatory cascade, and facilitates cytotoxicity. PMID: 18411291
  97. Up-regulated expression of GRP78 and GRP94 was possibly involved in pathogenesis, growth, invasion, and metastasis of gastric carcinomas. PMID: 18482745
  98. Grp94 with IgG promoted the angiogenic differentiation in HUVECs. PMID: 18554719
  99. Interaction of gp96 with CD91 is a productive event that directly and specifically triggers functional responses in plasmacytoid dendritic cells. PMID: 18941243
  100. Upregulation of GRP78 and GRP94 can significantly confer the chemoresistance to VP-16 in human lung cancer cell line SK-MES-1. PMID: 19212831

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Subcellular Location Endoplasmic reticulum lumen, Melanosome
Protein Families Heat shock protein 90 family
Database Links

HGNC: 12028

OMIM: 191175

KEGG: hsa:7184

STRING: 9606.ENSP00000299767

UniGene: Hs.192374

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