HTR7 Antibody, HRP conjugated

Code CSB-PA010899LB01HU
Size US$166
Order now
Have Questions? Leave a Message or Start an on-line Chat

Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) HTR7 Polyclonal antibody
Uniprot No.
Target Names
HTR7
Alternative Names
HTR7; 5-hydroxytryptamine receptor 7; 5-HT-7; 5-HT7; 5-HT-X; Serotonin receptor 7
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human 5-hydroxytryptamine receptor 7 protein (1-83AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.
Gene References into Functions
  1. Related GPCRs couple differently to Gs: preassociation between G protein and 5-HT7 serotonin receptor reveals movement of Galphas upon receptor activation. PMID: 29079700
  2. The dizygotic twins presented here carry a compound heterozygous variant in the HTR7 gene. No other coding sequence abnormalities (CNVs and SVs) were observed in their fully sequenced genomes consistent with either dominant or recessive inheritance. This provides a first suggestive genetic link between the 5-HT7 receptor and autism spectrum disorder in patients. PMID: 27380831
  3. Placental expression of HTR7 was significantly increased in women with pre-eclampsia compared to controls. PMID: 26797415
  4. PTP1B directly regulates STAT5 phosphorylation and its activation via the cAMP/PKA pathway downstream of the 5-HT7 receptor is involved in the suppression of beta-casein expression in MCF-12A cells PMID: 27016479
  5. Study shows that HTR7 variants are not related to the overall improvement in schizophrenia symptoms following perospirone or aripiprazole treatment PMID: 26609891
  6. Study demonstrated that binding of clozapine or olanzapine to the 5-HT7 receptor leads to antagonist-mediated lysosomal degradation by exposing key residues in the C-terminal tail that interact with GASP-1 PMID: 25706089
  7. This is a review of literature about how 5-HT7 receptor has been implicated in cognitive disturbances, sleep and circadian rhythmicity disorders, anxiety and depression PMID: 25228519
  8. Genetic variations in HTR7 serotonin receptor contribute to the predisposition for alcohol dependence. PMID: 25070732
  9. There is a cross-reactivity between 5-HT7 and 5-HT1A receptors and in this review they are shown to have a role in depressive disorders. PMID: 24935787
  10. the expression of 5-HT7 receptors in brain tissues was higher in the epilepsy group compared with the nonepileptic group; the results suggested that 5-HT7 receptors participate in the pathogenesis of temporal lobe epilepsy PMID: 22543085
  11. The interaction between RhoBTB3 and the 5-HT7a receptor strongly inhibits proteasomal degradation of the 5-HT7a receptor. PMID: 22245496
  12. The role of the 5-HT7 receptor in the central nervous system, is discussed. PMID: 21424680
  13. The association with rs7916403 in serotonin receptor gene HTR7 on chromosome 10q23 (combined P = 1.53 x 10), implicates the serotonergic system in the neurophysiological underpinnings of theta event-related brain oscillations. PMID: 21184583
  14. Ability of non-inactivating drugs to bind h5-HT(7) orthosteric sites and reverse wash-resistant effects of risperidone/9-OH-risperidone, also bound to h5-HT(7) orthosteric sites, is evidence for protomer-protomer interactions between h5-HT(7) homodimers. PMID: 20827463
  15. HEK293 cells stably or transiently expressing either of the 5-HT7 receptor splice variants show elevated basal adenylyl cyclase (AC) activity as well as concentration-dependent inhibition of basal AC activity by 5-HT7 antagonists (inverse agonism). PMID: 11906971
  16. The decrease in affinity of 5-HT and other 5-HT receptor agonists at the (Thr92Lys) h5-HT7 receptor may be associated with changes of sleep physiology and of actions of new 5-HT7 receptor agonists designed to treat circadian dysregulation. PMID: 15896881
  17. HTR7 is a susceptibility gene for schizophrenia in this Japanese group. PMID: 16192982
  18. This may indicate that the h5-HT7 receptor is part of a subfamily of G-protein-coupled receptors (GPCRs) possessing this property or that many GPCRs have the potential to be irreversibly blocked, but only select drugs can induce this effect. PMID: 16870886
  19. These observations suggest that PLAC-24 may play a role in the transport and the stabilisation of newly synthesised 5-HT(7) receptor towards the plasma membrane. PMID: 16935469
  20. Results support the essential role of Sp factors in regulating 5-HT(7) promoter activity. PMID: 17321075
  21. data demonstrate a role for sphingomyelin and gangliosides in regulating binding of [(3)H]5-HT to 5-HT(7) receptors; these observations further strengthen that actions of 5-HT via 5-HT(7) receptors are dependent upon lipid raft integrity PMID: 17428232
  22. Caveolin-1, specifically localized in cholesterol-enriched lipid rafts, appears to regulate constitutive and agonist-stimulated cell surface levels of 5-HT7 receptors via a clathrin-independent mechanism. PMID: 17936759
  23. Data show that 5-HT(7) receptors are involved in the modulation of learning and memory processes. PMID: 18243350
  24. The results of this study demonstrate that variations in the HTR7 gene may not be good genetic markers for predicting the therapeutic efficacy of risperidone. PMID: 19233240

Show More

Hide All

Subcellular Location
Cell membrane; Multi-pass membrane protein.
Protein Families
G-protein coupled receptor 1 family
Tissue Specificity
Isoform A is the predominant isoform in spleen, caudate and hippocampus. Isoform B is expressed at lower levels. Isoform D is a minor isoform in terms of expression.
Database Links

HGNC: 5302

OMIM: 182137

KEGG: hsa:3363

STRING: 9606.ENSP00000337949

UniGene: Hs.73739

icon of phone
Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
icon of address
Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
icon of social media
Join us with

Subscribe newsletter

Leave a message

* To protect against spam, please pass the CAPTCHA test below.
CAPTCHA verification
© 2007-2024 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1
webinars: DT3C facilitates antibody internalization X
Place an order now

I. Product details

*
*
*
*

II. Contact details

*
*

III. Ship To

*
*
*
*
*
*
*

IV. Bill To

*
*
*
*
*
*
*
*