HDAC10 Antibody

Code CSB-PA002914
Size US$100
  • Western Blot analysis of COS7 cells using Histone deacetylase 10 Polyclonal Antibody
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Product Details

Uniprot No.
Target Names
Alternative Names
DKFZP761B039 antibody; HD 10 antibody; HD10 antibody; HDA10_HUMAN antibody; HDAC 10 antibody; Hdac10 antibody; Histone deacetylase 10 antibody; MGC149722 antibody; OTTHUMP00000028555 antibody
Raised in
Species Reactivity
Synthesized peptide derived from the N-terminal region of Human Histone deacetylase 10.
Immunogen Species
Homo sapiens (Human)
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
It differs from different batches. Please contact us to confirm it.
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Tested Applications
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:10000
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Polyamine deacetylase (PDAC), which acts preferentially on N(8)-acetylspermidine, and also on acetylcadaverine and acetylputrescine. Exhibits attenuated catalytic activity toward N(1),N(8)-diacetylspermidine and very low activity, if any, toward N(1)-acetylspermidine. Histone deacetylase activity has been observed in vitro. Has also been shown to be involved in MSH2 deacetylation. The physiological relevance of protein/histone deacetylase activity is unclear and could be very weak. May play a role in the promotion of late stages of autophagy, possibly autophagosome-lysosome fusion and/or lysosomal exocytosis in neuroblastoma cells. May play a role in homologous recombination. May promote DNA mismatch repair.
Gene References into Functions
  1. HDAC10 structure and molecular function as a polyamine deacetylase has been reported. PMID: 28516954
  2. this study demonstrated that HDAC10 localizes and functions in the cytoplasm of lung cancer cells, thereby underscoring its potential role in the diagnosis and treatment of lung cancer PMID: 27449083
  3. HDAC10 regulates cyclin A2 expression by deacetylating histones near the let-7 promoter. PMID: 26240284
  4. study identifies an HDAC10-mediated regulatory mechanism controlling the DNA mismatch repair function of MSH2. PMID: 26221039
  5. Suggest HDAC10 expression as a prognostic marker for gastric cancer. PMID: 25337229
  6. this study is describing HDAC10 as a promoter of autophagy-mediated survival in neuroblastoma cells and identifying this HDAC isozyme as a druggable regulator of advanced-stage tumor cell survival. PMID: 24145760
  7. HDAC10 suppresses expression of matrix metalloproteinase (MMP) 2 and 9 genes, which are known to be critical for cancer cell invasion and metastasis PMID: 23897811
  8. results demonstrate that HDAC10 protects cancer cells from cytotoxic agents by mediating autophagy and identify this HDAC isozyme as a druggable regulator of advanced-stage tumor cell survival PMID: 23801752
  9. Histone deacetylases 9 and 10 are required for homologous recombination. PMID: 21247901
  10. HDAC10 is involved in transcriptional downregulation of TXNIP, leading to altered reactive oxygen species signaling in human gastric cancer cells. PMID: 20680488
  11. Results not only show that HDAC10 regulates melanogenesis but also demonstrate that the transcriptional activities of Pax3 and KAP1 are intimately linked to their acetylation status. PMID: 20032463
  12. another histone deacetylase PMID: 11739383
  13. molecular cloning and characterization of a novel class II histone deacetylase PMID: 11861901
  14. Reduced expression of histone deacetylase 10 is associated lung cancer PMID: 15305372
  15. Results suggest that the "T" allele of HDAC10-589C>T affect on the increased transcription activity, and might accelerate HCC development through increased expression of HDAC10. PMID: 17892858

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Subcellular Location
Cytoplasm. Nucleus.
Protein Families
Histone deacetylase family, HD type 2 subfamily
Tissue Specificity
Widely expressed with high levels in liver and kidney.
Database Links

HGNC: 18128

OMIM: 608544

KEGG: hsa:83933

STRING: 9606.ENSP00000216271

UniGene: Hs.26593

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