IDH3B Antibody

Datasheet

Code	CSB-PA05515A0Rb
Size	US$166
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Image	Western blot All lanes: IDH3B antibody at 2µg/ml Lane 1: Hela whole cell lysate Lane 2: Mouse kidney tissue Lane 3: Mouse gonadal tissue Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 43, 42, 26 kDa Observed band size: 43 kDa
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) IDH3B Polyclonal antibody

Uniprot No.

O43837

Target Names

IDH3B

Alternative Names

FLJ11043 antibody; H-IDHB antibody; Idh3B antibody; IDH3B_HUMAN antibody; Isocitrate dehydrogenase [NAD] subunit beta antibody; Isocitrate dehydrogenase [NAD] subunit beta; mitochondrial antibody; isocitrate dehydrogenase 3; beta subunit antibody; Isocitric dehydrogenase antibody; Isocitric dehydrogenase subunit beta antibody; MGC903 antibody; mitochondrial antibody; NAD(+)-specific ICDH antibody; NAD(+)-specific ICDH subunit beta antibody; NAD+-specific isocitrate dehydrogenase b subunit antibody; NAD+-specific isocitrate dehydrogenase beta antibody; OTTHUMP00000030023 antibody; OTTHUMP00000030024 antibody; RP46 antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial protein (35-385AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The IDH3B Antibody (Product code: CSB-PA05515A0Rb) is Non-conjugated. For IDH3B Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA05515B0Rb	IDH3B Antibody, HRP conjugated	ELISA
FITC	CSB-PA05515C0Rb	IDH3B Antibody, FITC conjugated
Biotin	CSB-PA05515D0Rb	IDH3B Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Plays a structural role to facilitate the assembly and ensure the full activity of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers.

Gene References into Functions

Human NAD-dependent isocitrate dehydrogenase (IDH) is a heterotetrameric mitochondrial enzyme with 2alpha:1beta:1gamma subunit ratio subunits shich share 40-52% identity in amino acid sequence. PMID: 20435888
IDPm activity appears to be modulated through enzymatic glutathionylation and deglutathionylation during oxidative stress PMID: 15653693
Asp192 is needed for optimal affinity of IDH beta subunit for nicotinamide-adenine dinucleotide (NAD) substrate, but is not critical for catalysis. PMID: 17432878
Homozygous for loss-of-function mutations in IDH3B is associated with retinitis pigmentosa. PMID: 18806796
The point mutations of isocitrate dehydrogenase are essentially unique to gliomas. PMID: 19498431

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Involvement in disease

Retinitis pigmentosa 46 (RP46)

Subcellular Location

Mitochondrion.

Protein Families

Isocitrate and isopropylmalate dehydrogenases family

Database Links

HGNC: 5385

OMIM: 604526

KEGG: hsa:3420

STRING: 9606.ENSP00000370223

UniGene: Hs.436405

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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