IFIT5 Antibody

Code CSB-PA011023LA01HU
Size US$166
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  • Western blot
    All lanes: IFIT5 antibody at 2µg/ml
    Lane 1: A375 whole cell lysate
    Lane 2: Jurkat whole cell lysate
    Lane 3: HepG2 whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 56, 51 kDa
    Observed band size: 56 kDa

  • Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA011023LA01HU at dilution of 1:100

  • Immunofluorescent analysis of HepG2 cells using CSB-PA011023LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) IFIT5 Polyclonal antibody
Uniprot No.
Target Names
IFIT5
Alternative Names
FLJ53857 antibody; FLJ92678 antibody; IFIT-5 antibody; IFIT5 antibody; IFIT5_HUMAN antibody; Interferon induced protein with tetratricopeptide repeats 5 antibody; Interferon-induced protein with tetratricopeptide repeats 5 antibody; Retinoic acid and interferon inducible 58 kDa protein antibody; Retinoic acid and interferon inducible protein (58kD) antibody; Retinoic acid- and interferon-inducible 58 kDa protein antibody; RI58 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Interferon-induced protein with tetratricopeptide repeats 5 protein (107-320AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The IFIT5 Antibody (Product code: CSB-PA011023LA01HU) is Non-conjugated. For IFIT5 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA011023LB01HU IFIT5 Antibody, HRP conjugated ELISA
FITC CSB-PA011023LC01HU IFIT5 Antibody, FITC conjugated
Biotin CSB-PA011023LD01HU IFIT5 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC, IF
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
IHC 1:20-1:200
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Interferon-induced RNA-binding protein involved in the human innate immune response. Has a broad and adaptable RNA structure recognition important for RNA recognition specificity in antiviral defense. Binds precursor and processed tRNAs as well as poly-U-tailed tRNA fragments. Specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Also recognizes and selectively binds AT-rich dsDNA. Additionally, as a mediator in innate immunity, regulates positively IKK-NFKB signaling by sinergizing the recruitment of IKK to MAP3K7.
Gene References into Functions
  1. IFIT5 promotes SeV-induced IKK phosphorylation and NF-kappaB activation by regulating the recruitment of IKK to TAK1. PMID: 26334375
  2. show that IFIT5 binds precursor and processed tRNAs, as well as other RNA polymerase III transcripts. Our findings establish the RNA recognition specificity of the human innate immune response protein IFIT5 PMID: 25092312
  3. TRIF-N-terminal helical domain shares structural similarity with IFIT5. PMID: 24311583
  4. IFIT5 consists of 24 alpha-helices that pack into a special "V"-like structure. PMID: 23774268
  5. IFIT5 recognizes cellular RNA instead of protein partners. PMID: 23317505
  6. crystal structures of human IFIT5, its complex with PPP-RNAs, and an amino-terminal fragment of IFIT1 PMID: 23334420

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Subcellular Location
Cell projection, ruffle membrane. Note=Colocalized with DDX58/RIG-I at cell surface ruffles. Localizes to actin-rich protrusions from the apical cell surface.
Protein Families
IFIT family
Database Links

HGNC: 13328

OMIM: 616135

KEGG: hsa:24138

STRING: 9606.ENSP00000360860

UniGene: Hs.252839

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