IL10RB Antibody

1. IFN-lambda4 suppressed HIV infection of macrophages. This IFN-lambda4-mediated HIV inhibition was compromised by the antibodies against IFN-lambda receptor complex, IFN-lambdaR1/IL-10R2. PMID: 30247785
2. IL-10 and IL-10R gene polymorphisms may not contribute to the susceptibility to MM but may be associated with the severity and prognosis of MM. In particular, IL-10RB K47E polymorphism may contribute to the poor prognosis of MM patients treated with thalidomide and/or bortezomib. PMID: 27405747
3. systemic mRNA expression of IL10RB strongly differentiated children who failed to achieve asthma control with triamcinolone administration PMID: 27665382
4. IL10R2 Overexpression promotes IL22/STAT3 signaling in colorectal carcinogenesis. PMID: 26130064
5. High IL10RB expression is associated with diffuse large B-cell lymphoma. PMID: 25733167
6. PAPL, IL10RB and DEPDC5 polymorphisms have an impact on progression of hepatitis B virus-related liver disease. PMID: 25032264
7. Results show that the distribution of IL10RB and IL28RA genotypes among the Hepatitis C virus-infected and control groups did not differ significantly. PMID: 24144988
8. Mutations in the IL10RB gene is associated with ulcerative colitis. PMID: 24216686
9. IL-10RB rs2834167 (A/G) polymorphism may be a potential biomarker for susceptibility to systemic lupus erythematosus. PMID: 23749100
10. Case Report: pediatric ulcerative colitis patient compound heterozygote for the IL10RB E47K polymorphism, inherited from his father. PMID: 24379584
11. IL10RB polymorphisms are associated with Crohn's disease. PMID: 22550014
12. distinct receptor complex that is utilized by all three IFN-lambda proteins for signaling and is composed of two subunits, a receptor designated CRF2-12 (also designated as IFN-lambdaR1) and a second subunit, CRF2-4 (also known as IL-10R2) PMID: 12483210
13. sensitivity to recombinant interleukin-26(IL-26) of various cell lines strictly correlated with the expression of IL-20 receptor 1 and blocking antibodies against either IL-10 receptor 2 or IL-20 receptor 1 inhibited IL-26-dependent signal transduction PMID: 15178681
14. These findings suggested that signaling through IL-10R2 may play a causative role in dcSSc. PMID: 18588853
15. The IL-22R and IL-10R2 binding sites are juxtaposed on adjacent IL-22 surfaces contributed mostly by helices A, D, and F and loop AB. PMID: 18675824
16. gene polymorphism in combination with IL-10 gene polymorphism is assiociated with GvHD in HLA-identical donor-recipient pairs PMID: 19409109
17. Inhibition of S100A11 gene expression impairs the ability of keratinocytes to control vaccinia virus replication via downregulation of IFN-lambda receptor IL-10R2. PMID: 19577285
18. The association with the susceptibility to HBV infection was only observed for IL10RB K47E when we compared the individuals with persistent HBV infection through nonmaternal transmission to the controls with asymptomatic self-limited HBV infection. PMID: 19714778

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HGNC: 5965

OMIM: 123889

KEGG: hsa:3588

STRING: 9606.ENSP00000290200

UniGene: Hs.654593